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A. The coiled coil domain is located close to the N-terminus of CHMP2B, between aminoacids 25 and 55. B. The microtubule-interacting and transport (MIT)-interacting region (MIR) is located at the C-terminus of CHMP2B, between aminoacids 201–211. This domain is responsible for the binding of CHMP2B to Vps4, the hexameric AAA + ATPase that disassembles the ESCRT complex prior formation of ILVs.
