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. Author manuscript; available in PMC: 2010 Nov 5.
Published in final edited form as: J Biol Chem. 2007 Jul 23;282(40):29130–29143. doi: 10.1074/jbc.M700111200

FIGURE 9. The tonic GABAA receptor-mediated current in epileptic stargazer (stg) CGC is mediated by a smaller percentage of α6-containing GABARs.

FIGURE 9

a, representative traces showing the reduction in holding current induced by the application of the α6/α4 antagonist furosemide, and the different sensitivity in +/+ and stg mice. b, scatter plot showing that furosemide reduces whole-cell conductance significantly more in +/+ mice than stg mice (+/+, −47 (interquartile range, −73, −36) pS/pF; stg, −19 (−37, 4) pS/pF; n = 9–13, p = 0.011, Mann Whitney test). c, zolpidem produces no significant change in whole-cell conductance in either stg or +/+ mice (+/+, 0.4 (−2, 2) %, n = 6, p = 0.8; stg, 0.7, (−3, 6) %, n = 6, p = 0.6, Wilcoxon matched pairs test).