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. 2010 Aug 25;11(3):1328–1339. doi: 10.1208/s12249-010-9511-z

Table II.

Molar Heat Capacities of the Solvate Formation Inline graphic

  Heat capacity at 25°C (J g−1 K−1) Molar heat capacity at 25°C (J/(mol K) Molar heat capacity of solvent (J/(mol K) (24) ΔC p at 25°C (J/(mol K)
Anhydrous nevirapine sample (NEV) 1.55 ± 0.014 412.76 ± 0.11 – –
Ethanolate (Form I) NEV+ (0.5) C2H5OH 1.66 ± 0.024 480.29 ± 0.05 112.24 11.41
Acetonitrilate (Form II)NEV + (0.5) CH3CN 1.74 ± 0.003 499.07 ± 0.04 91.70 40.46
Chloroformate (Form III) NEV+ (0.5)CHCl3 1.60 ± 0.027 520.61 ± 0.02 114.25 50.73
THF solvate (Form IV)NEV+ (0.5) THF 2.04 ± 0.004 616.79 ± 0.12 123.00 142.53
Mixed solvate of ethanol and water (Form V) NEV+ C2H5OH(0.5)+ H2O(0.5) 2.05 ± 0.019 611.59 ± 0.12 187.48 105.09
Toluene solvate (Form VI) NEV+ (0.5)Toluene 1.63 ± 0.007 509.16 ± 0.05 155.96 18.42