. 2010 Aug 25;11(3):1328–1339. doi: 10.1208/s12249-010-9511-z

Table III.

Enthalpies of Solution in Phosphate Buffer (pH 2) and Methanol at 25°C, Solubility, Enthalpies of Solvation of Nevirapine and its Solvates

	Solubility in phosphate buffer, pH 7 (mg/mL, Ssol, pH 7)	Molar enthalpy of solution (kJ mol⁻¹)		Molar enthalpy of mixing of solvent of the solvate (kJ mol⁻¹)		Enthalpy of solvation Δ_solv H (kJ mol⁻¹)	Molar enthalpy of solution in its own solvent (kJ mol⁻¹)
	Solubility in phosphate buffer, pH 7 (mg/mL, Ssol, pH 7)	Phosphate buffer (pH 2, Δ_sol H)	Methanol Δ_sol H (methanol)	Phosphate buffer (pH 2) Δ_mix H (buffer)	Methanol Δ_mix H (methanol)	Enthalpy of solvation Δ_solv H (kJ mol⁻¹)	Solvates (Δ_sol H ²)	Nevirapine (Δ_sol H ¹)
Anhydrous nevirapine sample (NEV)	0.133 ± 0.09	−5.91	5.80	–	–	–	–	–
Ethanolate (Form I) NEV+ (0.5) C₂H₅OH	0.229 ± 0.06	−14.14	−2.58	−0.108	−0.008	−2.37	8.44	6.07
Acetonitrilate (Form II)NEV+ (0.5) CH₃CN	0.135 ± 0.04	−3.14	8.62	0.289	−0.012	−10.12	35.26	25.14
Chloroformate (Form III) NEV+ (0.5) CHCl₃	0.201 ± 0.07	−12.83	−1.18	0.314	−0.201	−3.40	5.60	2.20
THF solvate (Form IV)NEV+ (0.5) THF	0.197 ± 0.04	−11.31	0.50	−0.219	0.109	−3.49	2.05	−1.44
Mixed solvate of ethanol and water (Form V) NEV+ C₂H₅OH(0.5) + H₂O(0.5)	0.130 ± 0.06	−2.83	8.88	−0.108	−0.008	−20.70	15.31	−5.39
Toluene solvate (Form VI) NEV+(0.5) Toluene	0.153 ± 0.06	−5.32	6.32	0.197	0.344	−4.35	20.02	15.67