Table I.
Ingredientsa | Formulae | |||||||
---|---|---|---|---|---|---|---|---|
F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | |
Lycoat NG73 | 15 | |||||||
Polyvinyl alcohol | 5 | 5 | ||||||
Hydroxypropyl methyl cellulose | 4 | |||||||
Hydroxyethyl cellulose | 3 | 3 | 1.5 | 3 | ||||
Alcohol | 15 | |||||||
Propylene glycol | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 | 7.5 |
Maltodextrin | 1.25 | 1.25 | 2.5 | 1.25 | 2.5 | |||
Lycoat RS780 | 1.25 | |||||||
Polyvinyl pyrrolidone K 90 | 10 | |||||||
Mentholb | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Distilled Water to | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
The concentration of the drug was 12.5 mg/4 cm2 of the film
aThe amounts are in grams
bAdded as 1 ml solution in ethyl alcohol