Table II.
Physico-mechanical Properties of Different Tianeptine Sodium Orodispersible Films
| Formulae | % Drug contenta | DT (Sec)b | Thickness (mm)a | TS (N/cm2)b | % E (cm%)b | E M |
|---|---|---|---|---|---|---|
| F1 | 102.70 ± 3.05 | 60.67 ± 1.15 | 0.32 ± 0.044 | 2.03 ± 0.012 | 91.08 ± 3.17 | 1.98 ± 0.057 |
| F2 | 97.27 ± 0.74 | 57.67 ± 2.52 | 0.10 ± 0 | 2.47 ± 0.1 | 81.69 ± 1.64 | 3.03 ± 0.18 |
| F3 | 103.93 ± 2.54 | 123.00 ± 4.36 | 0.37 ± 0.044 | 11.81 ± 2.5 | 39.57 ± 4.009 | 29.67 ± 3.38 |
| F4 | 98.79 ± 0.94 | 90.00 ± 10 | 0.36 ± 0.054 | 7.23 ± 0.27 | 36.71 ± 1.59 | 19.75 ± 1.58 |
| F5 | 97.99 ± 0.61 | 62.67 ± 8.33 | 0.12 ± 0.027 | 1.82 ± 0.02 | 65.50 ± 5.02 | 2.79 ± 0.24 |
| F6 | 101.81 ± 4.17 | 44.33 ± 5.13 | 0.19 ± 0.022 | NA | NA | NA |
| F7 | 98.36 ± 1.66 | 60.00 ± 4 | 0.22 ± 0.027 | 2.47 ± 0.32 | 144.05 ± 2.78 | 1.72 ± 0.26 |
| F8 | 102.64 ± 4.22 | 45.00 ± 5 | 0.11 ± 0.022 | 0.99 ± 0.22 | 69.95 ± 3.61 | 1.40 ± 0.24 |
TS tensile strength, EM modulus of elasticity, %E % elongation, DT disintegration time, NA not applicable
aValues are expressed as mean ± SD; n = 5
bValues are expressed as mean ± SD; n = 3