Table I.
Composition of Different Trimetazidine Tablet Formulas Prepared with Different Polymers
| Formula no. | Core tablet | Coat layer | |||||
|---|---|---|---|---|---|---|---|
| Drug (mg) | Filler up to 50 mg | Drug (mg) | Matrix former | Sodium bicarbonate (mg) | Spray-dried lactose (mg) | ||
| Type | Percenta | ||||||
| T1 | 25 | Spray-dried lactose | 15 | HPMC K4M/Carbopol 971P (7:1 ) | 30 | 20 | Up to 150 |
| T2 | 25 | 15 | 40 | 20 | |||
| T3 | 25 | 15 | 50 | 20 | |||
| T4 | 25 | Spray-dried lactose | 15 | HPMC K4M/Polycarbophil (7:1) | 30 | 20 | Up to 150 |
| T5 | 25 | 15 | 40 | 20 | |||
| T6 | 25 | 15 | 50 | 20 | |||
| T7 | 25 | Emcompress | 15 | HPMC K4M/Carbopol 971P (7:1) | 30 | 20 | Up to 150 |
| T8 | 25 | 15 | 40 | 20 | |||
| T9 | 25 | 15 | 50 | 20 | |||
| T10 | 25 | HPMC 15 cps | 15 | HPMC K4M/Carbopol 971P (7:1) | 30 | 20 | Up to 150 |
| T11 | 25 | 15 | 40 | 20 | |||
| T12 | 25 | 15 | 50 | 20 | |||
| T13 | 25 | Guar gum | 15 | HPMC K4M/Carbopol 971P (7:1) | 30 | 20 | Up to 150 |
| T14 | 25 | 15 | 40 | 20 | |||
| T15 | 25 | 15 | 50 | 20 | |||
aPercent from total tablet weight (200 mg)