Table V.

Comparative Pharmacokinetic Parameters of Midazolam Hydrochloride Following Administration of Intravenous and Nasal In Situ Gels in Rabbits (dose = 2 mg/kg)

Parameter	Intravenous solution	FCM gel	HPMC gel	Carbopol gel
C max (ng/ml)	73.64 ± 5.23	199.59 ± 9.28	151.47 ± 7.22	164.07 ± 6.85
t max (min)	0.00	20.00 ± 5.11	60.00 ± 5.68	45.00 ± 3.66
AUC(0–t) (min(ng/ml))	32,671.50 ± 90.56	25,311.30 ± 115.05	18,034.30 ± 101.45	22,074.10 ± 96.72
AUC(t–∞) (min(ng/ml))	865.87 ± 37.25	6,907.46 ± 55.41	1,191.83 ± 45.26	3,684.71 ± 60.58
AUCtotal (min(ng/ml))	33,537.40 ± 101.25	32,218.80 ± 86.25	19,226.10 ± 97.25	25,758.90 ± 95.46
t 1/2 (min)	58.78 ± 6.32	133.52 ± 8.07	68.44 ± 5.28	99.68 ± 4.89
MRT (min)	71.61 ± 5.05	196.20 ± 5.35	130.16 ± 6.58	162.50 ± 7.25
CL (×10−5) (mg/kg/(ng/ml)min)	5.79 ± 6.95	6.02 ± 7.58	10.93 ± 8.15	7.53 ± 5.66

Data represent mean ± SD (n = 3)