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. 2010 Aug 26;11(3):1359–1367. doi: 10.1208/s12249-010-9515-8

Table III.

Friability (% Weight Loss) Results for Marketed Levothyroxine Tablets for Whole, Hand-Split, and Splitter-Split Tablets

  Whole Hand-split Splitter-split
L-1 0.21 0.47 0.40
L-2 0.05 0.49 1.02
L-3 0.09 0.16 3.24
L-4 0.09 0.25 0.30
L-5 0.19 0.69 0.87