Table I.
Hydrophilic–Lipophilic Balance Spreadsheet Design in Accordance with Individual Surfactant Contribution—First Run of Experiments
| Formulation | Tween 20® | Span 80® | Final HLB value | ||
|---|---|---|---|---|---|
| % | HLB contribution | % | HLB contribution | ||
| F1 | 100.0 | 16.7 | 0.0 | 0.0 | 16.7 |
| F2 | 91.9 | 15.4 | 8.1 | 0.3 | 15.7 |
| F3 | 83.9 | 14.0 | 16.1 | 0.7 | 14.7 |
| F4 | 75.8 | 12.7 | 24.2 | 1.0 | 13.7 |
| F5 | 67.7 | 11.3 | 32.3 | 1.4 | 12.7 |
| F6 | 59.7 | 10.0 | 40.3 | 1.7 | 11.7 |
| F7 | 51.6 | 8.6 | 48.4 | 2.1 | 10.7 |
| F8 | 43.5 | 7.3 | 56.5 | 2.4 | 9.7 |
| F9 | 35.5 | 5.9 | 64.5 | 2.8 | 8.7 |
| F10 | 27.4 | 4.6 | 72.6 | 3.1 | 7.7 |
| F11 | 19.4 | 3.2 | 80.6 | 3.5 | 6.7 |
| F12 | 11.3 | 1.9 | 88.7 | 3.8 | 5.7 |
| F13 | 3.2 | 0.5 | 96.8 | 4.2 | 4.7 |
| F14 | 0.0 | 0.0 | 100.0 | 4.3 | 4.3 |
F formulation, HLB hydrophilic–lipophilic balance