Table 3.

Effect-size measures for the mutant–control comparisons that were identified as statistically significant (p < 0.05) when assessed with a three-level random-effect nested ANOVA

Allele	Genotype comparison	Gender	Parameter	p Value	q Value	η2	Cohen’s d	Difference in mean (control–mutant) [HR (bpm) or BP (mmHg)]
Tpm1 tm1aWtsi	HETvWT	F	Heart rate	0.0366	0.1881	0.211	1.03	33.1
Mta1 tm1aWtsi	HETvWT	F	Heart rate	0.0021	0.0432	0.267	1.21	41.7
	HETvWT	M	Heart rate	0.0328	0.1759	0.148	0.83	24.6
	HETvWT	F	Diastolic BP	0.0178	0.1292	0.168	0.90	10.9
	HOMvWT	M	Heart rate	0.0009	0.0278	0.322	1.38	51.6
	HOMvWT	F	Heart rate	0.0035	0.0617	0.304	1.32	56.4
Akt2 tm1Wcs	HOMvWT	M	Heart rate	0.025	0.1468	0.133	0.78	−5.1
	HOMvWT	F	Diastolic BP	0.0193	0.1323	0.065	0.53	8.0
	HOMvWT	F	Systolic BP	0.0223	0.1448	0.060	0.51	8.13
Herc3 tm1a(EUCOMM)Wtsi	HOMvWT	M	Heart rate	0.025	0.1468	0.103	0.68	−39.5
	HOMvWT	F	Heart rate	0.04	0.1955	0.097	0.65	−32.2
Epc1 tm1aWtsi	HETvWT	M	Systolic BP	0.0114	0.0946	0.132	0.78	−21.1
	HETvWT	M	Diastolic BP	0.0083	0.0788	0.142	0.81	−20.1
	HETvWT	M	Heart rate	0.0051	0.0650	0.180	0.94	−46.5
	HETvWT	F	Heart rate	0.0052	0.0650	0.164	0.89	−35.1
Baz1b tm1a(KOMP)Wtsi	HETvWT	M	Heart rate	0.0412	0.1955	0.040	0.41	−25.4
	HETvWT	F	Heart rate	0.0235	0.1449	0.062	0.51	−28.6
Mysm1 tm1a(KOMP)Wtsi	HETvWT	M	Systolic BP	0.0064	0.0658	0.111	0.71	−10.9
	HETvWT	M	Diastolic BP	0.0054	0.0650	0.107	0.69	−10.5
Tmc1 dn	HOMvHET	F	Heart rate	0.0007	0.0278	0.055	0.48	−40.1
Cadm1 tm1.2Brd	HOMvWT	F	Heart rate	0.0003	0.0278	0.236	1.11	−49.1
Cdh23 v	HOMvHET	F	Systolic BP	0.0498	0.2194	0.045	0.43	−7.4
	HOMvHET	F	Heart rate	0.0013	0.0321	0.175	0.92	−127.2
Magi2 tm1Grnt	HETvWT	M	Systolic BP	0.0115	0.0946	0.089	0.62	−10.2
	HETvWT	M	Diastolic BP	0.0469	0.2143	0.048	0.45	−7.2
Mta3 tm1a(KOMP)Wtsi	HOMvWT	M	Diastolic BP	0.0281	0.1576	0.024	0.32	35.7
	HOMvWT	F	Heart rate	0.0127	0.0321	0.066	0.53	18.7
Brd7 tm1aWtsi	HETvWT	M	Heart rate	0.0058	0.0650	0.050	0.46	16.1

BP blood pressure, HR heart rate

Within the genotype comparison column, WT indicates that mice were wild type for the gene of interest. HET and HOM indicate that mice were heterozygous and homozygous, respectively, for the targeted allele