Skip to main content
. Author manuscript; available in PMC: 2010 Nov 5.
Published in final edited form as: Biometrics. 2007 Dec;63(4):1245–1252. doi: 10.1111/j.1541-0420.2007.00801.x

Table 3.

The minimal number of centenarian alleles (L) needed to detect dependence in 2 × 2 × 2 tables for 27 SNPs of three candidate longevity genes when α = 0.05, 1 − β = 0.8 and the number of young controls N = 400. The first 4 columns represent the four specified marginal frequencies (p, q, r, s); the fifth, sixth, seventh, and eighth columns represent four log odds ratios (logρ1, logρ2, logρca, and logρam). The ninth column is the resulting power assuming α = 0.05 and L = 242. The last column is the minimal L necessary to detect nonrandom associations in different 2 × 2 × 2 tables under the conditions mentioned above.

Gene SNPs p q r s Logρ1 Logρ2 Logρca Logρam Power L
APOE SNPs_l 0.0297 0.8812 0.1134 0.5464 −2.8679 −2.7275 −0.5261 −0.3857 0.9993 54
SNPs_2 0.3000 0.8800 0.3125 0.5417 −0.1759 −1.2528 0.5660 −0.5108 0.9996 5
SNPs_3 0.0693 0.8713 0.0928 0.5361 −0.1301 −2.0794 −0.9102 1.2993 0.9974 23
SNPs_4 0.6200 0.8800 0.2917 0.5417 −0.2305 −0.1699 −0.3483 −0.2877 0.1274 4738
SNPs_5 0.6600 0.8800 0.2500 0.5417 −1.0498 −0.2252 −0.4389 0.3857 0.7076 310
SNPs_6 0.0600 0.8800 0.1087 0.5652 −3.0681 −0.1603 −1.7243 1.5041 0.9939 85
SNPs_7 0.1000 0.8800 0.1042 0.5417 −0.6931 −1.3398 −0.5978 1.4351 0.9555 19
HRAS1 SNPs_8 0.1200 0.8800 0.0928 0.5361 −0.4447 −2.0794 −0.3494 2.1748 0.9977 13
SNPs_9 0.2200 0.8800 0.2292 0.5417 −0.6650 −0.9426 0.3466 0.0690 0.9730 8
SNPs_10 0.1200 0.8800 0.2083 0.5417 −1.6094 −1.2747 −0.2657 0.0690 0.9998 13
SNPs_11 0.2200 0.8800 0.2292 0.5417 −0.6650 −0.9426 0.3466 0.0690 0.9730 8
SNPs_12 0.0891 0.8713 0.0722 0.5361 −0.1823 −1.7473 −0.2657 1.2993 0.9483 23
SNPs_13 0.1089 0.8713 0.0309 0.5361 −0.4308 −0.5653 1.1648 1.2993 0.1201 5013
SNPs_14 0.0297 0.8812 0.0204 0.5408 −2.8679 −0.1671 −0.5261 2.1748 0.8893 182
SNPs_15 0.3600 0.8800 0.3125 0.5417 −1.4553 −0.0488 0.0488 1.4553 0.9058 180
LASS1 SNPs_16 0.0600 0.8800 0.3125 0.5417 −1.4351 −2.2192 −1.0076 −1.7918 0.9999 27
SNPs_17 0.3600 0.8800 0.2292 0.5417 −0.6592 −2.5745 −0.1892 3.0445 0.9999 4
SNPs_18 0.1000 0.8800 0.3125 0.5417 −0.6931 −2.2192 −0.2657 −1.7918 0.9999 16
SNPs_19 0.2000 0.8800 0.0928 0.5361 −0.2513 −2.0794 0.3466 2.1748 0.9970 15
APOE SNPs_20 0.0297 0.8713 0.0204 0.5408 −1.2763 −0.1671 0.1900 1.2993 0.3236 3312
SNPs_21 0.0196 0.8725 0.0515 0.5464 −1.9924 −1.6487 −0.5261 −0.1823 0.9484 100
SNPs_22 0.0196 0.8725 0.0515 0.5464 −1.9924 −1.6487 −0.5261 −0.1823 0.9484 100
SNPs_23 0.0297 0.8812 0.0309 0.5464 −2.8679 −0.9067 −0.5261 1.4351 0.9341 136
SNPs_24 0.0196 0.8725 0.0309 0.5464 −1.9924 −0.9067 −0.5261 0.5596 0.6632 406
HRAS1 SNPs_25 0.0196 0.8725 0.0309 0.5464 −1.9924 −0.9067 −0.5261 0.5596 0.6632 406
LASS1 SNPs_26 0.0297 0.8713 0.0204 0.5408 −1.2763 −0.1671 0.1900 1.2993 0.3236 3312
SNPs_27 0.0495 0.8713 0.0204 0.5408 −0.5596 −0.1671 0.9067 1.2993 0.1356 4495