Table 1. Unaltered HCC Development by Histopathology, HCC Size, and Blood Chemistries in 24 Killed Animals.
| Weeks After Last DEN Injection | n | Histopathologic Diagnosis | Lung Metastasis | Mean HCC Size (cm) (Range) | Blood Chemistries | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| GOT (U/L) | GPT (U/L) | Total Bilirubin (mg/dL) | AKP (U/L) | GGT (U/L) | Albumin (g/dL) | |||||
| 5–7 | 9 | GST-P positive foci | — | — | 187 ± 65 | 96 ± 33 | 0.05 ± 0.05 | 176 ± 126 | 62 ± 40 | 3.74 ± 0.75 |
| 9–13 | 7 | GST-P positive foci and nodule 4 of 7 HCC | — | 0.26 (0.1–0.5) | 122 ± 52 | 65 ± 35 | 0.02 ± 0.04 | 184 ± 26 | 33 ± 29 | 3.76 ± 0.42 |
| 18–25 | 4 | HCC with vascular invasion | 1/4 | 1.7 (0.5–2.0) | 347 ± 173 | 335 ± 219 | 0.08 ± 0.05 | 231 ± 56 | 90 ± 48 | 4.13 ± 0.26 |
| 32–40 | 4 | HCC with vascular invasion | 2/4 | 2.15 (0.6–5.0) | 831 ± 1,122 | 690 ± 880 | 0.25 ± 0.13 | 318 ± 126 | 291 ± 205 | 3.73 ± 0.70 |
Note: Values are mean ± SD
Abbreviations: GST-P, glutathione S transferase placental form; GOT, glutamic-oxaloacetic transaminase; GPT, glutamic-pyruvic transaminase; AKP, alkaline phosphatase; GGT, gamma-glutamyl transpeptitase.