Fig 2.

Effect of castration on the concentration-time profile of docetaxel (10 mg/kg, iv) in (A) liver and (B) plasma of noncastrated (gold squares) and castrated (blue squares) Sprague-Dawley rats and on the hepatic expression of solute carriers and adenosine triphosphate binding cassette transporters as measured by (C) microarray or (D) real-time quantitative polymerase chain reaction (n = three to four animals per time point) in noncastrated (gold bars) and castrated (blue bars) Sprague-Dawley rats. (E) Transport of docetaxel in water-injected control (gold bar) Xenopus laevis oocytes or those expressing the rat Oat2 transporter (blue bar, n = 22 observations per group). All data are shown as mean (symbol or bar) and SE (error bar). *P < .05; †P < .01; ‡P < .001.