Appendix.
Formulas used to calculate derived bone histomorphometric indices from primary measurements
| Abbreviation | Parameter | Unit | Formula |
|---|---|---|---|
| Structural | |||
| BV/TV | Bone volume/tissue volume | % | Bone area/tissue area × 100 |
| Static formation | |||
| OV/BV | Osteoid volume/bone volume | % | Osteoid area/bone area × 100 |
| O.Th | Osteoid thickness | μm | (Osteoid area/osteoid perimeter) × 2/1.2 |
| Dynamic formation | |||
| MS/BS | Mineralizing surface/bone surface | % | (Double-label perimeter + 1/2 single-label perimeter)/bone perimeter × 100 |
| MAR | Mineral apposition rate | μm/d | (Distance between labels/interlabel period)/1.2 |
| MLT | Mineralization lag time | days | O.Th/AjAr |
| OMT | Osteoid maturation time | days | O.Th/MAR |
| BFR/BS | Bone formation rate/bone surface | μm3/μm2 per year | MAR × MS/BS × 3.65 |