Table 3.

Association of age and overt proteinuria with death and ESRD

Variable	Adjustment	Death			ESRDa
		HR	95% CI	P	SHR	95% CI	P
Age (per 10 years)	Model 1a	2.05	(1.49 to 2.82)	<0.001	0.87	(0.64 to 1.18)	0.364
	Model 2a	1.87	(1.35 to 2.60)	<0.001	0.81	(0.60 to 1.10)	0.170
	Model 3a	1.70	(1.20 to 2.41)	0.003	0.67	(0.49 to 0.92)	0.013
Overt proteinuria	Model 1a	1.38	(0.78 to 2.45)	0.270	6.03	(2.73 to 13.3)	<0.001
	Model 2a	1.39	(0.78 to 2.47)	0.265	5.55	(2.56 to 12.0)	<0.001
	Model 3a	1.13	(0.62 to 2.05)	0.697	4.97	(2.23 to 11.1)	<0.001

Model 1a: Overt proteinuria, sex, and estimated glomerular filtration ratio.

Model 1b: Age, sex, and estimated glomerular filtration ratio.

Model 2a/b: Model 1a/b + prior cardiovascular disease, diabetes and hypertension.

Model 3a/b: Model 2a/b + smoking history, hemoglobin and renin-angiotensin inhibitors.

^aPatients with stage 5 CKD were excluded.