Table 3.

PD parameters at baseline on day 1 versus day 15 (predose)

Parameter	Control Subjects			ESRD Subjects
	NAC 600 mg			NAC 600 mg			NAC 1200 mg
	Day 1	Day 15	%Δ	Day 1	Day 15	%Δ	Day 1	Day 15	%Δ
HCY (μg/ml)	1.3 ± 0.6	1.1 ± 0.5a	12.4 ± 8.9	3.1 ± 1.2b	2.4 ± 0.8a	21.5 ± 16.9	3.3 ± 1.4b	2.4 ± 1.1a	24.8 ± 7.1
CYS (μg/ml)	32.0 ± 5.2	31.5 ± 5.6	1.8 ± 5.4	43.4 ± 8.6b	44.3 ± 11.6	−1.7 ± 1.6	39.0 ± 4.1b	40.8 ± 5.7	−4.8 ± 10.9
ADMA (μM)	0.41 ± 0.08	0.38 ± 0.08	5.4 ± 18.5	0.58 ± 0.07b	0.58 ± 0.09	1.4 ± 11.0	0.59 ± 0.09b	0.60 ± 0.06	−1.2 ± 11.7
SDMA (μM)	0.49 ± 0.09	0.48 ± 0.11	0.3 ± 12.1	2.26 ± 0.66b	2.19 ± 0.59	1.5 ± 17.1	2.35 ± 0.50b	2.14 ± 0.34	7.5 ± 10.1
ARG (μM)	96.4 ± 28.9	86.4 ± 16.4	6.7 ± 21.1	86.0 ± 17.5	74.8 ± 16.2a	12.5 ± 12.8	69.0 ± 20.6	72.5 ± 26.0	−8.6 ± 36.4
GSH (μM)	1060 ± 122	1059 ± 56	−0.9 ± 11.6	986 ± 204	967 ± 131	−0.8 ± 21.8	1121 ± 161	1105 ± 118	0.9 ± 6.5
CARB (nM/mg protein)	3.17 ± 0.50	3.17 ± 1.11	−1.0 ± 34.4	4.33 ± 1.32b	3.95 ± 1.13	5.6 ± 23.0	5.07 ± 1.54b	4.26 ± 1.28	10.5 ± 31.2

%Δ, percentage change from day 1. For conversion of HCY to SI units, 7.397 mg/L = 1 μmol/L. For conversion of CYS to SI units, 8.251 mg/L = 1 μmol/L. Data expressed as mean ± SD.

^aP < 0.05 versus day 1.

^bP < 0.05 versus control subjects day 1.