Table 3.
Parameter | Control Subjects |
ESRD Subjects |
|||||||
---|---|---|---|---|---|---|---|---|---|
NAC 600 mg |
NAC 600 mg |
NAC 1200 mg |
|||||||
Day 1 | Day 15 | %Δ | Day 1 | Day 15 | %Δ | Day 1 | Day 15 | %Δ | |
HCY (μg/ml) | 1.3 ± 0.6 | 1.1 ± 0.5a | 12.4 ± 8.9 | 3.1 ± 1.2b | 2.4 ± 0.8a | 21.5 ± 16.9 | 3.3 ± 1.4b | 2.4 ± 1.1a | 24.8 ± 7.1 |
CYS (μg/ml) | 32.0 ± 5.2 | 31.5 ± 5.6 | 1.8 ± 5.4 | 43.4 ± 8.6b | 44.3 ± 11.6 | −1.7 ± 1.6 | 39.0 ± 4.1b | 40.8 ± 5.7 | −4.8 ± 10.9 |
ADMA (μM) | 0.41 ± 0.08 | 0.38 ± 0.08 | 5.4 ± 18.5 | 0.58 ± 0.07b | 0.58 ± 0.09 | 1.4 ± 11.0 | 0.59 ± 0.09b | 0.60 ± 0.06 | −1.2 ± 11.7 |
SDMA (μM) | 0.49 ± 0.09 | 0.48 ± 0.11 | 0.3 ± 12.1 | 2.26 ± 0.66b | 2.19 ± 0.59 | 1.5 ± 17.1 | 2.35 ± 0.50b | 2.14 ± 0.34 | 7.5 ± 10.1 |
ARG (μM) | 96.4 ± 28.9 | 86.4 ± 16.4 | 6.7 ± 21.1 | 86.0 ± 17.5 | 74.8 ± 16.2a | 12.5 ± 12.8 | 69.0 ± 20.6 | 72.5 ± 26.0 | −8.6 ± 36.4 |
GSH (μM) | 1060 ± 122 | 1059 ± 56 | −0.9 ± 11.6 | 986 ± 204 | 967 ± 131 | −0.8 ± 21.8 | 1121 ± 161 | 1105 ± 118 | 0.9 ± 6.5 |
CARB (nM/mg protein) | 3.17 ± 0.50 | 3.17 ± 1.11 | −1.0 ± 34.4 | 4.33 ± 1.32b | 3.95 ± 1.13 | 5.6 ± 23.0 | 5.07 ± 1.54b | 4.26 ± 1.28 | 10.5 ± 31.2 |
%Δ, percentage change from day 1. For conversion of HCY to SI units, 7.397 mg/L = 1 μmol/L. For conversion of CYS to SI units, 8.251 mg/L = 1 μmol/L. Data expressed as mean ± SD.
P < 0.05 versus day 1.
P < 0.05 versus control subjects day 1.