Figure 1.
Chloroquine terminates stable high-frequency VT/VF in the mouse heart. A) Dominant frequency maps at the onset of pacing-induced VT (DFmax=43 Hz), 5 min after 10 μM chloroquine (30 Hz), and before arrhythmia termination (21 Hz). B) Plot of normalized VT/VF DFmax in 5 mouse hearts. After the addition of 10 μM chloroquine, the normalized DFmax is displayed at 1-min intervals. VT/VF terminated in 5 of 5 mouse hearts. C) Volume conducted ECG: termination of polymorphic VT and resumption of normal sinus rhythm.