Figure 2.
Antifibrillatory effects of chloroquine in the rabbit heart. A) Dominant frequency maps at the onset of pacing-induced VF (DFmax=20 Hz, red), 2 min after 10 μM chloroquine (15 Hz), and before arrhythmia termination (9 Hz). B) Plot of normalized VF DFmax in 4 mouse hearts. After the addition of 10 μM chloroquine, the normalized DFmax is displayed at 1-min time intervals. VT/VF terminated in 4 (plotted) of 5 rabbit hearts. C) Volume conducted ECG: termination of polymorphic VT and resumption of normal sinus rhythm.