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. 2010 Nov;24(11):4178–4186. doi: 10.1096/fj.10-160648

Figure 4.

Figure 4.

Structure-activity analysis of tannic acid analogs. A) Representative short-circuit current data in TMEM16A-expressing FRT cells showing inhibition following activation of TMEM16A Cl− current by a small-molecule calcium agonist (Caact, 5 μM). Tannic acid or indicated analogs added as shown. Tannic acid (TA; 100 μM) was added where indicated. B) Dose-response data for inhibition of Cl− current in TMEM16A-expressing FRT cells (top panel) and T84 cells (bottom panel) (means ± se, n=3–4). Some error bars are smaller than symbol size. IC50 values are summarized in Fig. 3.