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. 2010 Nov;24(11):4178–4186. doi: 10.1096/fj.10-160648

Figure 5.

Figure 5.

Potent inhibition of TMEM16A/CaCC Cl− conductance by red wine and green tea. A) Short-circuit current data (top and middle panels) and dose-response summary (bottom panel) for inhibition of ATP-induced CaCC Cl− current in T84 cells by a red wine and a green tea. CFTRinh-172 (20 μM) was present to inhibit CFTR. B) Inhibition of Cl− current in TMEM16A-expressing FRT cells. C) Inhibition of ATP-induced CaCC Cl− current in T84 cells by wine and grape tannins. D) Inhibition of Cl− current by 2 major polyphenols present in green tea, epigallocatechin-3-gallate (EGCG), and epicatechin-3-gallate (ECG) (top panels), in TMEM16A-expressing FRT cells (middle panels) and T84 cells (bottom panels).