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. 2010 Nov;24(11):4178–4186. doi: 10.1096/fj.10-160648

Figure 6.

Figure 6.

Gallotannins inhibit arterial smooth muscle contraction and intestinal Cl− secretion. A) Mouse aortic smooth muscle contraction. Contraction-relaxation data showing inhibition of phenylephrine (PE, 1 μM) induced contraction by a California and French red wine and a green tea (top panel), and tannic acid and EGCG (bottom panel). Control experiments with only PE added showed sustained contraction with <2% decrease in arterial tension over 45 min. Representative of 3 sets of experiments. B) Left panel: short-circuit current of mouse ileum and colon showing inhibition of carbachol (1 mM)-stimulated Cl− current by 10 min tannic acid pretreatment (100 μM, ileum; 50 μM, colon). Right panel: summary of peak carbachol-stimulated current by tannic acid in mouse colon (means ± se, n=5). *P < 0.001 vs. 0 tannic acid, ANOVA with Tukey-Kramer post hoc test.