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. 2010 Oct;88(4):769–778. doi: 10.1189/jlb.0410220

Figure 3. sLRP1 levels in mouse and human plasma are increased by inflammation.

Figure 3.

(A) LPS or normal saline was injected i.p. in mice. Blood samples were recovered by cardiac puncture. Plasma was isolated. sLRP1 levels were determined by RAP ligand blotting. The total number of animals studied in 3 independent experiments was control, n=13; LPS treatment for 1 h, n=7; LPS treatment for 3 h, n=9; LPS treatment for 6 h, n=7. Results were analyzed by densitometry (mean±sem; *P<0.05). (B) sLRP1 in human plasma samples was determined by ELISA. The patients were diagnosed with FM, n=9; OA, n=18; RA, n=20; or SLE, n=17 (mean±sem; *P<0.05). (C) CRP in human samples was determined by ELISA. Samples selected at random from those assayed in B included those from patients with FM, n=8; OA, n=11; RA, n=11; and SLE, n=10. One-way ANOVA was used to determine statistical significance. Tukey’s post hoc analysis was used to assess differences between treatment groups.