Table 4.

Mediators of Neurocognitive Change in EFML and Psychomotor Speed

Mediator	ΔNeurocognitive Performance	Adjustment for Mediator	DASH+WM vs UC	DASH+WM Sobel Test	DASH-A vs UC	DASH-A Sobel Test
EFML
Δ weight, kg	−0.30‡	Unadjusted	0.35*		§	§
		Adjusted	0.46*	Z101= −0.62
Δ peak V̇ O2, mL/kg per min	0.19**	Unadjusted	0.35*		§	§
		Adjusted	0.10†	Z101=2.14†
ΔSBP, mm Hg	−0.16†	Unadjusted	0.35*		§	§
		Adjusted	0.26‡	Z101=1.53
Psychomotor speed
Δweight, kg	−0.36†	Unadjusted	0.26†		0.23†	Z101=0.944
		Adjusted	−0.09	Z101=2.21†	0.20†
Δpeak V̇O2, mL/kg per min	0.13†	Unadjusted	0.26†		0.23†	Z101=0.72
		Adjusted	0.10	Z101=1.72‡	0.21†
ΔSBP, mm Hg	−0.04	Unadjusted	0.26†		0.23†	Z101=−0.13
		Adjusted	§	Z101=−0.13	0.23†

Contrasts are adjusted for pretreatment neurocognitive performance, age, education, IMT, Framingham Stroke Risk Profile, and abdominal adiposity.

^*P<0.01.

^†P<0.05.

^‡P<0.10.

^§Data show mediation analyses that were not conducted because either there was no main effect of treatment or changes in the mediating variable were not significantly related to neurocognitive outcomes.