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. 2010 Jul 7;116(15):2627–2634. doi: 10.1182/blood-2010-04-262048

Table 1.

Candidate gene SNPs used in association studies

Gene Protein identification dbSNP or chromosomal location* Cytoband MAF
ADRA2A α-2A-adrenergic receptor chr10: 112 839 580 10q24-q26 0.41
F2R Coagulation factor II (thrombin) receptor; proteinase-activated receptor 1 (PAR-1) rs168753 5q13 0.14
FCGR2A IgG Fc receptor type IIa chr1: 161 479 745 1q23 0.44
GNB3 Guanine nucleotide-binding protein beta-3 subunit variant rs5443 12p13 0.45
GP1BA Platelet glycoprotein Ib, α subunit rs6065 17pter-p12 0.10
GP6 Platelet glycoprotein VI rs1613662 19q13.4 0.16
ITGA2 Integrin subunit-α2 rs1126643 rs28095 rs1801106 5q11.2 0.38 0.36 0.08
ITGA2B Integrin subunit-αIIb rs5911 17q21.32 0.41
ITGB3 Integrin subunit-β3 rs5918 17q21.32 0.17
P2RY1 Purinogenic receptor P2Y1 rs1065776 3q25.2 0.05
P2RY12 Purinogenic receptor P2Y12 rs6809699 3q24-q25 0.14
PTGS1 Prostaglandin-endoperoxide synthase 1; cyclooxygenase-1 (COX-1) rs3842787 9q32-q33.3 0.06
TBXA2R Thromboxane A2 receptor rs1131882 rs4523 rs5758 19p13.3 0.13 0.30 0.45
*

NCBI SNP database (dbSNP) identification number (Build 131) or flanking nucleotide sequence (when SNP has not been assigned a dbSNP number).

CATTCCCAACTCTCTCTCTCTTTTT(G/A)AAGAAAAATGCTAAGGGCAGCCCTG.

AATGGAAAATCCCAGAAATTCTCCC(A/G)TTTGGATCCCACCTTCTCCATCCCA.