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. 2010 Jul 8;116(15):2793–2802. doi: 10.1182/blood-2010-01-265942

Figure 5.

Figure 5

Increased neutrophil apoptosis in patients with G6PC3 deficiency resulting from homozygous inheritance of G6PC3 G260R. Neutrophils from both patients and 2 healthy donors (HD) were cultured at 37°C for 2 hours (left panels) or 4 hours (right panels) in medium alone or medium with the addition of tumor necrosis factor (TNFα) or thapsigargin. Flow cytometry was then performed. Apoptotic cells are defined as annexin V+. Dead cells are defined as propidium iodide–positive (PI)+. Data are from a single experiment performed after the patients were treated for 7 months with G-CSF.