Table 2.

Bone marrow and corresponding blood cell counts

	Biopsy no. 1		Biopsy no. 2		Boztug et al117	Normal values
	Patient 1, male	Patient 2, female	Patient 1, male	Patient 2, female
Blood ANC, cells/μL	190	540	120	550	ND	∼ 4000
Age, y	9	5	13	9	0.1	(1-20)
Blasts, %	1	1	4	4	0.9	1.2 (0-3)
Promyelocytes, %	10	5	14	18	11.4	1.8 (0-5)
Myelocytes, %	7	3	12	11	2.8	16 (9-25)
Metamyelocytes, %	17	3	18	18	0.5	23 (14-34)
Bands + PMNs, %	36	18	20	17	0	13 (5-29)
Eosinophilic granulocytes, %	0	0	0	0	0.3	4 (1-9)
Basophilic granulocytes, %	0	0	0	0	0	0.1 (0-0.8)
Monocytes, %	8	7	5	4	9.4	ND
Lymphocytes, %	10	27	9	10	24	16 (5-36)
Plasma cells, %	0	1	2	5	0	ND
Erythroid progenitors, %	11	35	16	13	50.6	23 (6-38)
M:E ratio	7.2	1.1	4.6	5.5	0.5	3 (1-12)

Data are ANC, age, and cell distribution in 2 different bone marrow samples obtained for each patient; the mean values reported by Boztug et al¹⁷ for 4 patients with G6PC3 mutation R253H,¹⁷ and normal mean values (range) for children (n = 92).²⁴

PMNs indicates polymorphonuclear leukocytes; ND, not described; and M:E, myeloid:erythroid ratio.