Table 1. Concept analysis of the identified dysferlin protein complex partners.
A | Myoblasts | Myotubes | Tissue |
1 | MYOF | MYOF | MYOF |
2 | VCL | TRIM72 | VCL |
3 | EIF3B | LDB3 | EIF3B |
4 | CAPZB | VCL | DCTN1 |
5 | DCTN1 | EIF3B | LMNA |
6 | ANXA2 | CAPZB | HSP90B1 |
7 | UTRN | ACTN2 | NEDD4L |
8 | EIF2S1 | TTN | HSPA5 |
9 | LMNA | ANXA2 | STAT1 |
B | Myoblasts | Myotubes | Tissue |
1 | kinesin activity | Translation Initiation | kinesin activity |
2 | dynein activity | protein disulfide isomerase activity | dynein activity |
3 | Myosin ATPase | chaperonin activity | Translation Initiation |
4 | membrane protein traffic | heat-shock response | chaperonin activity |
5 | Antigen Processing | ribonucleoprotein complex location | heat-shock response |
6 | Translation Initiation | ubiquitin activity | ubiquitin activity |
7 | transfer RNA | Actin myofilament | cell-cell adhesion |
8 | heat-shock response | phosphatase | citric acid cycle |
9 | chaperonin activity | Keratins | |
10 | ribosomal protein activity | pre-replicative complex | |
11 | ribonucleoprotein complex location | ||
12 | Growth Cones | ||
13 | actin cap | ||
14 | actin cortical patch | ||
15 | Cytoskeleton | ||
16 | Intermediate Filaments | ||
17 | ubiquitin activity | ||
18 | nucleocytoplasmic transport | ||
19 | phosphatase | ||
20 | phosphatase | ||
21 | cyclin-dependent protein kinase activity |
A) For each data set the proteins were assigned to concept profiles (summary of all concepts such as proteins, diseases and GO terms to associate with a given protein identifier), and conceptual overlap with dysferlin was calculated. The 9 proteins with strongest conceptual overlap are listed and include described interaction partners (in bold). B) Identified proteins were first clustered and subsequently annotated with concepts. Representative concepts for the uncovered clusters are shown for each data set (full table in S3).