Table 1.
Characteristics of the study population at baseline and at follow up (25 weeks of treatment)
| Baseline | Follow up | |||||
|---|---|---|---|---|---|---|
| Control (n = 21) |
Fenofibrate (n = 22) |
P | Control (n = 21) |
Fenofibrate (n = 22) |
P | |
| Age (years) | 64 ± 8 | 67 ± 7 | 0.33 | - | - | - |
| Male gender (%) | 16 (76) | 18 (82) | 0.65 | - | - | - |
| Diabetes mellitus (%) | 6 (29) | 6 (27) | 0.92 | - | - | - |
| Hypertension (%) | 11 (52) | 11 (50) | 0.88 | - | - | - |
| Current smoker (%) | 5 (24) | 6 (27) | 0.80 | - | - | - |
| Body mass index (kg/m2) | 24.5 ± 2.5 | 23.7 ± 1.9 | 0.27 | 24.3 ± 2.4 | 23.9 ± 2.4 | 0.65 |
| Total cholesterol (mg/dL) | 199 ± 33 | 189 ± 31 | 0.33 | 180 ± 38* | 171 ± 31* | 0.44 |
| Triglycerides (mg/dL) | 110 ± 48 | 106 ± 39 | 0.75 | 102 ± 41 | 72 ± 37† | 0.02 |
| HDL cholesterol (mg/dL) | 45 ± 11 | 46 ± 10 | 0.84 | 46 ± 11 | 50 ± 12* | 0.34 |
| LDL cholesterol (mg/dL) | 110 ± 29 | 102 ± 24 | 0.32 | 96 ± 33* | 88 ± 27* | 0.40 |
| HbA1c (%) hs-CRP (mg/L) |
6.1 ± 1.4 1.33 ± 1.26 |
6.3 ± 1.6 1.93 ± 2.03 |
0.54 0.41 |
6.0 ± 1.3 1.63 ± 2.19 |
6.2 ± 1.7 1.75 ± 3.56 |
0.66 0.93 |
| CET activity (pmol/μL/h) | 88.4 ± 40.7 | 82.6 ± 50.4 | 0.68 | 94.4 ± 59.4 | 57.4 ± 35.1* | 0.02 |
Data are presented as the mean ± SD. LDL = Low-density lipoprotein, HDL = High-density lipoprotein, hs-CRP = high sensitivity C-reactive protein, CET = cholesterol ester transfer. Statistical differences between the control group and the fenofibrate group were analyzed by unpaired Student's t-test. Statistical differences between values at baseline and at follow up were analyzed by paired Student's t-test. * P < 0.05 and † P < 0.01 Baseline vs. Follow up.