Table 2.
Effect of fenofibrate on lipoprotein subclass profiles analyzed by HPLC in patients with CAD
| Baseline | Follow up | |||||
|---|---|---|---|---|---|---|
| Control (n = 21) |
Fenofibrate (n = 22) |
P | Control (n = 21) |
Fenofibrate (n = 22) |
P | |
| Cholesterol | ||||||
| Chylomicron-C (mg/dL) | 0.9 ± 0.6 | 0.8 ± 0.6 | 0.54 | 0.7 ± 0.6 | 0.5 ± 0.4† | 0.20 |
| Large VLDL-C (mg/dL) | 20.7 ± 6.7 | 20.5 ± 7.2 | 0.93 | 17.8 ± 6.3 | 16.1 ± 6.4† | 0.41 |
| Medium VLDL-C (mg/dL) | 16.0 ± 5.0 | 13.8 ± 3.8 | 0.11 | 13.3 ± 4.9* | 11.9 ± 3.3* | 0.28 |
| Small VLDL-C (mg/dL) | 9.4 ± 2.6 | 8.5 ± 2.2 | 0.23 | 8.1 ± 2.4* | 8.3 ± 2.2 | 0.72 |
| Large LDL-C (mg/dL) | 20.5 ± 4.7 | 19.8 ± 3.8 | 0.60 | 18.4 ± 5.3 | 19.1 ± 4.6 | 0.68 |
| Medium LDL-C (mg/dL) | 27.2 ± 6.2 | 26.9 ± 6.0 | 0.91 | 25.0 ± 8.2 | 23.4 ± 6.0* | 0.47 |
| Small LDL-C (mg/dL) | 19.5 ± 5.0 | 19.7 ± 5.5 | 0.88 | 17.9 ± 6.9 | 15.9 ± 4.4† | 0.27 |
| Very small LDL-C (mg/dL) | 14.3 ± 4.1 | 15.2 ± 4.6 | 0.48 | 13.2 ± 5.4 | 12.2 ± 3.2† | 0.49 |
| Very large HDL-C (mg/dL) | 4.1 ± 1.2 | 4.7 ± 1.5 | 0.14 | 4.6 ± 1.8* | 3.9 ± 1.5* | 0.18 |
| Large HDL-C (mg/dL) | 7.4 ± 3.9 | 8.5 ± 4.1 | 0.37 | 8.8 ± 4.6* | 7.1 ± 4.2 | 0.21 |
| Medium HDL-C (mg/dL) | 12.3 ± 3.4 | 12.0 ± 3.3 | 0.80 | 12.4 ± 3.4 | 15.4 ± 4.4† | 0.02 |
| Small HDL-C (mg/dL) | 9.8 ± 2.4 | 9.3 ± 2.4 | 0.51 | 9.8 ± 2.1 | 11.9 ± 2.8† | 0.009 |
| Very small HDL-C (mg/dL) | 7.0 ± 1.1 | 7.3 ± 1.8 | 0.46 | 6.9 ± 1.2 | 8.8 ± 1.8† | < 0.001 |
| Triglycerides | ||||||
| Chylomicron-TG (mg/dL) | 1.9 ± 1.4 | 1.7 ± 1.5 | 0.68 | 1.7 ± 2.1 | 0.9 ± 1.0† | 0.14 |
| Large VLDL-TG (mg/dL) | 22.3 ± 4.4 | 26.2 ± 11.5 | 0.15 | 23.7 ± 12.4 | 15.1 ± 9.5† | 0.01 |
| Medium VLDL-TG (mg/dL) | 9.7 ± 2.3 | 11.0 ± 4.6 | 0.25 | 10.1 ± 4.0 | 7.4 ± 3.7† | 0.03 |
| Small VLDL-TG (mg/dL) | 4.6 ± 1.0 | 5.1 ± 2.0 | 0.30 | 4.9 ± 1.7 | 3.8 ± 1.7† | 0.05 |
| Large LDL-TG (mg/dL) | 6.3 ± 1.5 | 6.6 ± 2.0 | 0.54 | 6.3 ± 2.0 | 5.7 ± 2.1* | 0.37 |
| Medium LDL-TG (mg/dL) | 7.2 ± 1.7 | 7.6 ± 1.8 | 0.42 | 6.9 ± 2.1 | 6.8 ± 2.2* | 0.86 |
| Small LDL-TG (mg/dL) | 5.4 ± 1.3 | 6.1 ± 1.7 | 0.13 | 5.1 ± 1.7 | 5.1 ± 1.6† | 0.99 |
| Very small LDL-TG (mg/dL) | 5.0 ± 1.2 | 5.9 ± 1.9 | 0.09 | 4.8 ± 1.7 | 4.6 ± 1.6† | 0.68 |
| Very large HDL-TG (mg/dL) | 1.8 ± 0.4 | 1.8 ± 0.4 | 0.90 | 1.9 ± 0.6 | 1.2 ± 0.5† | < 0.001 |
| Large HDL-TG (mg/dL) | 2.6 ± 1.1 | 2.9 ± 1.2 | 0.40 | 3.3 ± 1.5 | 1.5 ± 1.0† | < 0.001 |
| Medium HDL-TG (mg/dL) | 4.2 ± 1.3 | 4.3 ± 1.2 | 0.77 | 4.5 ± 1.3 | 3.5 ± 1.5* | 0.03 |
| Small HDL-TG (mg/dL) | 3.5 ± 1.1 | 3.7 ± 0.9 | 0.56 | 3.6 ± 0.9 | 3.5 ± 1.5 | 0.89 |
| Very small HDL-TG (mg/dL) | 3.2 ± 0.7 | 3.6 ± 0.8 | 0.07 | 3.2 ± 0.7 | 3.2 ± 1.2 | 0.95 |
Data are presented as the mean ± SD. CAD = coronary artery disease, VLDL = Very low-density lipoprotein, LDL = Low-density lipoprotein, HDL = High-density lipoprotein, -C = -cholesterol, -TG = -triglycerides, Statistical differences between the control group and the fenofibrate group were analyzed by unpaired Student's t-test. Statistical differences between values at baseline and at follow up were analyzed by paired Student's t-test. * P < 0.05 and † P < 0.01 Baseline vs. Follow up.