Table 3.
Lesions and procedural characteristics at the time of intervention and follow-up angiography
| Control (n = 19) |
Fenofibrate (n = 19) |
P | Fenofibrate | |||
|---|---|---|---|---|---|---|
| High CET activity (n = 9) |
Low CET activity (n = 10) |
P | ||||
| Target vessel | ||||||
| LAD (%) | 6 (42) | 5 (24) | 0.49 | 2 (20) | 3 (27) | 0.93 |
| LCX (%) | 3 (21) | 6 (29) | 3 (30) | 3 (27) | ||
| RCA (%) | 5 (36) | 10 (48) | 5 (50) | 5 (46) | ||
| Complex lesion (%) | 14 (74) | 10 (53) | 0.18 | 6 (67) | 4 (44) | 0.34 |
| Restenosis lesion (%) | 3 (16) | 3 (16) | 1.00 | 1 (11) | 2 (20) | 0.60 |
| Before stenting | ||||||
| Reference diameter (mm) | 2.67 ± 0.51 | 2.61 ± 0.53 | 0.73 | 2.72 ± 0.61 | 2.60 ± 0.39 | 0.61 |
| Minimal lumen diameter (mm) | 0.44 ± 0.15 | 0.55 ± 0.20 | 0.10 | 0.59 ± 0.21 | 0.53 ± 0.18 | 0.55 |
| Diameter stenosis (%) | 82.8 ± 6.1 | 78.2 ± 8.6 | 0.09 | 77.4 ± 9.4 | 78.6 ± 8.8 | 0.78 |
| Lesion length (mm) | 11.8 ± 4.3 | 13.4 ± 6.2 | 0.40 | 12.9 ± 6.1 | 13.8 ± 6.8 | 0.78 |
| Procedural data | ||||||
| Maximum balloon pressure (atm) | 12.9 ± 4.7 | 12.3 ± 4.8 | 0.68 | 12.3 ± 4.9 | 12.6 ± 4.8 | 0.80 |
| Balloon to vessel ratio | 1.13 ± 0.21 | 1.16 ± 0.17 | 0.63 | 1.17 ± 0.17 | 1.16 ± 0.18 | 0.88 |
| Stent segment length (mm) | 13.6 ± 3.8 | 13.5 ± 3.8 | 0.90 | 14.3 ± 5.0 | 13.2 ± 2.7 | 0.56 |
| Immediately after stenting | ||||||
| Minimal lumen diameter (mm) | 2.79 ± 0.65 | 2.56 ± 0.50 | 0.26 | 2.56 ± 0.39 | 2.56 ± 0.59 | 1.00 |
| Diameter stenosis (%) | 9.4 ± 10.8 | 10.5 ± 12.8 | 0.79 | 9.7 ± 9.5 | 11.2 ± 15.4 | 0.80 |
| Follow-up | ||||||
| Minimal lumen diameter (mm) | 1.57 ± 0.56 | 1.64 ± 0.60 | 0.73 | 1.35 ± 0.62 | 1.90 ± 0.46 | 0.04 |
| Diameter stenosis (%) | 44.3 ± 19.4 | 38.6 ± 22.0 | 0.44 | 51.9 ± 21.6 | 26.6 ± 14.8 * | 0.01 |
| Late lumen loss (mm) | 1.22 ± 0.51 | 0.91 ± 0.64 | 0.15 | 1.21 ± 0.61 | 0.64 ± 0.56 * | 0.05 |
| Loss index Restenosis (%) |
0.52 ± 0.23 5 (26) |
0.44 ± 0.29 4 (21) |
0.39 0.70 |
0.60 ± 0.28 3 (33) |
0.29 ± 0.23 * 1 (10) |
0.02 0.21 |
Data are mean ± SD. CET = cholesterol ester transfer. LAD = left anterior descending coronary artery, LCX = left circumflex coronary artery, RCA = right coronary artery. The high CET activity and low CET activity were defined as the upper and lower 50th percentile of CET activity levels at follow-up, respectively. Complex lesion was defined as lesion type B2 and C according to the American College of Cardiology/American Heart Association grading system. Statistical differences of parameters between each group were analyzed by unpaired Student's t-test. * P < 0.05 and ** P < 0.01 vs. control group.