Table 1.
ORs (95% CIs) for bladder cancer for quartile levels of average long-term level of household THMs and for selected SNPs.
| Measure | n (cases/controls)a | OR (95% CI)b | p-Value |
|---|---|---|---|
| Average THM level at home (μg/L, age 15 to index age) | |||
| ≤ 8.0 | 156/175 | 1.0 | |
| > 8.0–26.0 | 153/174 | 1.2 (0.8–1.9) | |
| > 26.0–49.0 | 197/169 | 1.8 (1.1–2.9) | |
| > 49.0 | 174/196 | 1.8 (0.9–3.5) | |
| ptrend | 0.029 | ||
| Polymorphism | |||
|
NAT2 | |||
| Fast | 243/299 | 1.00 | |
| Slow | 428/403 | 1.33 (1.06–1.68) | 0.01 |
|
GSTM1 | |||
| Present | 257/366 | 1.00 | |
| Null | 420/346 | 1.77 (1.41–2.22) | < 0.001 |
|
GSTT1 | |||
| Null | 136/160 | 1.00 | |
| Present | 542/550 | 1.21 (0.92–1.59) | 0.13 |
|
GSTZ1 | |||
| rs1046428, T82M | |||
| CC | 405/402 | 1.00 | |
| CT | 213/213 | 1.06 (0.82–1.35) | 0.67 |
| TT | 31/29 | 1.07 (0.61–1.86) | 0.82 |
| rs7975, E32K | |||
| GG | 314/330 | 1.00 | |
| AG | 275/276 | 1.06 (0.83–1.34) | 0.66 |
| AA | 68/63 | 1.22 (0.82–1.81) | 0.33 |
| rs7972, G42R | |||
| GG | 553/572 | 1.00 | |
| AG | 100/91 | 1.16 (0.84–1.61) | 0.36 |
| AA | 4/6 | 0.69 (0.18–2.56) | 0.57 |
|
CYP2E1 | |||
| rs2070676 | |||
| CC | 479/474 | 1.00 | |
| CG | 161/166 | 0.93 (0.71–1.21) | 0.59 |
| GG | 9/5 | 2.03 (0.62–6.62) | 0.24 |
| rs2031920 | |||
| CC | 590/569 | 1.00 | |
| CT | 37/42 | 0.76 (0.47–1.23) | 0.27 |
| TT | 0/0 | — | |
| rs8192766 | |||
| GG | 528/533 | 1.0 | |
| GT | 118/106 | 1.05 (0.77–1.42) | 0.77 |
| TT | 3/7 | 0.32 (0.08–1.30) | 0.11 |
a
Numbers of cases or controls per measure may not equal the total number of cases (680) and controls (714) because of missing genotype data.
b
OR (95% CI) from logistic regression adjusted for age (continuous), sex, smoking status (never/former/current), size of the municipality of longest residence until 18 years of age, education (three strata), geographic area (six strata), and overall quality of interview.