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. Author manuscript; available in PMC: 2011 Nov 5.
Published in final edited form as: J Proteome Res. 2010 Sep 23;9(11):5943–5951. doi: 10.1021/pr1007043

Figure 2.

Figure 2

Representative ESI-MS and MS/MS data revealing the doxorubicin-induced down-regulation of HMG-CoA synthase. Shown are the MS for the [M+2H]2+ ions of HMG-CoA synthase peptide IGVFSYGSGLAATLYSLK and IGVFSYGSGLAATLYSLK* (‘K*’ designates the heavy lysine) from the forward (A) and reverse (B) SILAC experiments. Depicted in (C) and (D) are the MS/MS for the [M+2H]2+ ions of IGVFSYGSGLAATLYSLK and IGVFSYGSGLAATLYSLK*, respectively.