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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Pharmacol Res. 2010 Sep 17;62(6):465–474. doi: 10.1016/j.phrs.2010.09.002

Figure 2.

Figure 2

Effect of dimethylsphingosine (DMS) on vasomotor responses of isolated vessels. Contractile responses of basilar and femoral arteries of rat to either 100 mmol/L KCl (A, B) or cumulative concentrations of 5-hydroxytryptamine (5-HT; C, D), sphingosine-1-phosphate (S1P, E) or phenylephrine (PE, F) following 1h incubation with vehicle (ethanol, 0.1%), 5, 10 or 20 µmol/L DMS. Contractile responses are normalized to vasoconstriction induced by exposure to 100 mmol/L KCl in the same preparation before DMS-treatment. Data are mean ± SEM of 5 independent measurements.

In A and B *P<0.05, **P<0.01 versus Control, † P<0.05 vs. DMS 5 µmol/L, ‡ vs. DMS 10 µmol/L; one-way ANOVA and Tukey test. In B and E, P<0.01 DMS vs. control and DMS 20 µmol/L vs. DMS 5 µmol/L; two-way ANOVA.