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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Pharmacol Res. 2010 Sep 17;62(6):465–474. doi: 10.1016/j.phrs.2010.09.002

Figure 4.

Figure 4

Effect of FTY720 on vasomotor responses of isolated vessels. Basilar and femoral arteries of rat were challenged with cumulative concentrations of 5-hydroxytryptamine (5-HT; A, B), sphingosine-1-phosphate (S1P, C) or phenylephrine (PE, D) following 1h incubation with vehicle (H2O) or 10 µmol/L FTY720. Contractile responses are normalized to vasoconstriction induced by exposure to 100 mmol/L KCl in the same preparation before FTY720-treatment. Data are mean ± SEM of 5 independent measurements. In A and C P<0.05 and P<0.01, respectively; two-way ANOVA.