hMre11 anneals complementary
ssDNA molecules. Two complementary 50 nt ssDNAs (MJ19 and MJ20),
one of which was radiolabeled, were incubated with 10 nM hMre11,
hKu70/80, hRad52 or without protein. After deproteinization,
samples were analyzed by native PAGE and autoradiography. Lane 1, incubation
without protein; lane 2, dsDNA, annealed by heating and slow cooling;
lane 3, incubation with hMre11; lane 4, incubation with hKu70/80
heterodimer; lane 5, incubation with hRad52. The positions of ssDNA
and dsDNA are indicated.