Tabel II.

Thioesterase Functions and Substrate Specificities

Family	General function	EC number	Preferred substrate specificity (if known)
TE1	Acyl-CoA hydrolase	3.1.2.1, 2.8.3.–	Acetyl-CoA
TE2	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.2, 2.3.1.65	Palmitoyl-CoA, bile-acid-CoA
TE3	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.20, 3.1.1.2, 3.1.1.5	Medium- to long-chain acyl-CoA
TE4	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.2, 3.1.2.27	Short- to long-chain acyl-CoA, palmitoyl-CoA, choloyl-CoA
TE5	Acyl-CoA hydrolase	3.1.2.–	Long-chain acyl-CoA, 3,5-tetradecadienoyl-CoA
TE6	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.1, 3.1.2.2, 3.1.2.18, 3.1.2.19, 3.1.2.20	Short- to long-chain acyl-CoA, C4–C18
TE7	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.1, 3.1.2.2, 3.1.2.20	Short- to long-chain acyl-CoA
TE8	Acyl-CoA hydrolase	3.1.2.–	Short- to long-chain acyl-CoA, C6–C18
TE9	Acyl-CoA hydrolase	3.1.2.–, 3.1.2.18	Short- to long-chain acyl-CoA, 4-hydroxybenzoyl-CoA
TE10	Acyl-CoA hydrolase	3.1.2.23	4-Hydroxybenzoyl-CoA
TE11	Acyl-CoA hydrolase	3.1.2.–	4-Hydroxybenzoyl-CoA
TE12	Acyl-CoA hydrolase	3.1.2.–	1,4-Dihydroxy-2-napthoyl-CoA
TE13	Acyl-CoA hydrolase	3.1.2.–	Short and medium-chain acyl-CoA, several hydroxyphenylacetyl-CoA substrates
TE14	Acyl-ACP hydrolase	3.1.2.–, 3.1.2.14	Short- to long-chain acyl-ACP, C8–C18
TE15	Acyl-ACP hydrolase	—	—
TE16	Acyl-ACP hydrolase	3.1.2.14a	Long-chain acyl-ACP, various polyketides and non-ribosomal peptides
TE17	Acyl-ACP hydrolase	3.1.2.14b	Several polyketides
TE18	Acyl-ACP hydrolase	3.1.2.–, 3.1.2.14	Medium-chain acyl-ACP, various polyketides and nonribosomal peptides
TE19	Acyl-ACP hydrolase	2.3.1.–	Myristoyl-ACP
TE20	Protein-palmitoyl hydrolase	3.1.2.–, 3.1.2.22	Palmitoyl-protein
TE21	Protein-acyl hydrolase	3.1.2.–, 3.1.1.1	—
TE22	Glutathione hydrolase	3.1.2.12, 3.1.1.1, 3.1.1.6	S-Formylglutathione
TE23	Glutathione hydrolase	3.1.2.6	d-Lactoylglutathione

^aTE domain. FASs, PKSs, and NRPs can have several EC numbers such as 2.3.1.85, 2.3.1.94, 2.3.1.–, 2.7.7.–, and 5.1.1.–.

^bTE domain of PKSs.