Tabel VI.
TE Family and Clan Mechanisms
| Clan | Family | Catalytic residuesa | PDB file | Producing organism |
|---|---|---|---|---|
| — | TE1 | — | — | — |
| — | TE2 | Ser294, His422, Asp388 | 3HLK | Homo sapiens |
| Ser232,b His360,b Asp326b | 3K2I | H. sapiens | ||
| — | TE3 | Ser10, His157, Asp154 | 1IVN, 1JRL, 1J00, 1U8U, 1V2G | Escherichia coli |
| — | TE4 | Asp204, Thr228, Gln278 | 1C8U | E. coli |
| TE-A | TE5 | Asp13c | 1NJK | E. coli |
| — | TE6 | Asn24, Asp213 | 2Q2B, 2V1O | Mus musculus |
| Asp44 | 1YLI, 3BJK | Haemophilus influenzae | ||
| Asp34 | 3D6L | Campylobacter jejuni | ||
| Asp36b | 3B7K | H. sapiens | ||
| Asp245b | 2QQ2 | H. sapiens | ||
| — | TE7 | — | — | — |
| TE-B | TE8 | Asn50, Asp65, Ser83, Gly57 | 2F0X, 3F5O, 2H4Ub | H. sapiens |
| Asn50,b Asp65,b Ser83,b Gly57b | 2CY9 | M. musculus | ||
| TE-A | TE9 | Tyr7, Asp11, His18 | 2PZH | Helicobacter pylori |
| Tyr14,b Asp18,b His25b | 1S5U | E. coli | ||
| Tyr23,b Asp28,b His35b | 3HM0 | Bartonella henselae | ||
| Tyr11,b Asp15,b His22b | 1Z54 | Thermus thermophilus | ||
| TE-A | TE10 | Asp17 | 1BVQ, 1LO7, 1LO8, 1LO9 | Pseudomonas sp. |
| TE-B | TE11 | Gly65, Glu73 | 1Q4S, 1Q4T, 1Q4U | Arthrobacter sp. |
| Gly55,b Glu63b | 1VH9 | E. coli | ||
| Gly55,b Glu63b | 2B6E, 1SC0, 3LZ7 | H. influenzae | ||
| TE-A | TE12 | Asp19c | 2HX5 | Prochlorococcus marinus |
| TE-B | TE13 | Gly40,b Asp48 | 1WLU, 1J1Y, 1WM6, 1WLV, 1WN3, 2DSLb | T. thermophilius |
| Gly53, Asp61 | 2FS2, 1PSUb | E. coli | ||
| — | TE14 | Cys264, His229, Asn227 | Arabidopsis thaliana | |
| — | TE15 | Asn19, Tyr29, Arg37 | 2W3X | Micromonospora echinospora |
| TE-C | TE16 | Ser2308, His2481, Asp2338 | 1XKT, 2PX6 | H. sapiens |
| Ser80, His207, Asp107 | 1JMK | Bacillus subtilis | ||
| Ser84, His201, Asp111 | 2CB9, 2CBG | B. subtilis | ||
| TE-C | TE17 | Ser142, His259, Asp169 | 1KEZ, 1MO2 | Saccharopolyspora erythraea |
| Ser148, His268, Asp176 | 1MN6, 1MNA, 1MNQ | S. erythraea | ||
| Ser148, His268, Asp176 | 2HFK, 2HFJ, 2H7X, 2H7Y | Streptomyces venezuelae | ||
| TE-C | TE18 | Ser94, His228, Asp200 | 3FLA, 3FLB | Amycolatopsis mediterranei |
| — | TE19 | Ser114, His241, Asp211 | 1THT | Vibrio harveyi |
| TE-D | TE20 | Ser115, His289, Asp233 | 1EI9, 1EH5, 1EXW | Bos taurus |
| Ser115, His289, Asp233 | 3GRO | H. sapiens | ||
| Ser111, His283, Asp228 | 1PJA | H. sapiens | ||
| TE-D | TE21 | Ser114, His199, Asp168 | 1AUO, 1AUR | Pseudomonas fluorescens |
| Ser114, His203, Asp169 | 1FJ2 | H. sapiens | ||
| Ser113,b His197,b Asp166b | 3CN7, 3CN9 | Pseudomonas aeruginosa | ||
| — | TE22 | Ser120, His231, Asp202 | 2UZ0 | Streptococcus pneumoniae |
| Ser161, His276, Asp241 | 1PV1, 2C6B | S. cerevisae | ||
| Ser149, His260, Asp226 | 3FCX | H. sapiens | ||
| Ser147, His256, Asp223 | 3E4D | Agrobacterium tumefaciens | ||
| Ser147, His258, Asp255 | 3LS2 | Pseudoalteromonas haloplanktis | ||
| Ser148,b His257,b Asp224b | 3I6Y | Oleispira antartica | ||
| — | TE23 | Various His and Asp residues, along with Zn, Fe, or Mn ions | 1QH3 | H. sapiens |
a
As proposed by the authors in the literature cited, except as noted.
b
Predicted by the authors of this article based upon the position of catalytic residues in superimposed structures within families.
c
Predicted by the authors of this article based upon the position of catalytic residues in superimposed structures within clan TE-A.