Tabel I.
bZIP Heptad position | Amino acid position within NS4Ba | Natural amino acid polymorphismsb | Hydrophobic or charged residues versus all polymorphisms |
---|---|---|---|
a | 22 | FIL | 6/9 (hydrophobic) |
29 | ST | ||
36 | ATV | ||
43 | W | ||
d | 25 | L | |
32 | A | 5/5 (hydrophobic) | |
39 | MV | 2/5 (leucine) | |
46 | L | ||
e | 26 | Q | 3/5 (charged) |
33 | E | ||
40 | EQ | ||
47 | E | ||
g | 28 | A | 1/7 (charged) |
35 | AIV | ||
42 | KN | ||
49 | F |
Numbering according to the NS4B protein within the prototype strain HCVJ.
Natural polymorphisms in alphabetical order with hydrophobic or charged residues in italic/bold.