Tabel I.
Natural Amino Acid Polymorphisms Within the bZIP Motif of HCV Genotype 1 at Positions Important for the bZIP Functionality
| bZIP Heptad position | Amino acid position within NS4Ba | Natural amino acid polymorphismsb | Hydrophobic or charged residues versus all polymorphisms |
|---|---|---|---|
| a | 22 | FIL | 6/9 (hydrophobic) |
| 29 | ST | ||
| 36 | ATV | ||
| 43 | W | ||
| d | 25 | L | |
| 32 | A | 5/5 (hydrophobic) | |
| 39 | MV | 2/5 (leucine) | |
| 46 | L | ||
| e | 26 | Q | 3/5 (charged) |
| 33 | E | ||
| 40 | EQ | ||
| 47 | E | ||
| g | 28 | A | 1/7 (charged) |
| 35 | AIV | ||
| 42 | KN | ||
| 49 | F |
a
Numbering according to the NS4B protein within the prototype strain HCVJ.
b
Natural polymorphisms in alphabetical order with hydrophobic or charged residues in italic/bold.