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. 2010 May 17;19(7):1395–1404. doi: 10.1002/pro.420

Figure 3.

Figure 3

Examples of local changes after methylation. Residues from methylated structures are shown in yellow, while unmodified structures are marked in grey. Dashed lines mark hydrogen bonds, while blue arrows show the change in the position of the side chain. A: Formation of hydrogen bond. In the unmodified molecule the distance between the Lys9 side chain nitrogen atom and the oxygen atom from the carboxyl group of Glu37 changes from 4.0 Å (PDB deposit: 1Z27) to 2.7 Å after methylation (PDB deposit: 1Z1Y). B: Different conformation of dmLys (PDB deposit: 2FCL) in comparison with Lys residue (PDB deposit: 2EWR) strengthens the hydrogen bond formed by Glu57 (the donor–acceptor distance changes from 3.0 to 2.7 Å).