Table 1.
List of miRNAs which have Tumor Suppressor or Oncogenic Activity
| miRNA | Targeted molecules | Altered in tumors | References |
|---|---|---|---|
| Tumor suppressor activity | |||
| let-7 | RAS, PRDM1, HMGA2, c-Myc, E2F, cyclin D2 | Lung, ovarian cancer, breast, and colorectal cancers | (60–64) |
| miR-15/miR-16 | Bcl-2, Wt-1 | Gastric and lung cancers | (65–67) |
| miR-34 | E2F3, Notch1, CDK4, CDK5 | Breast, pancreatic, colon cancers | (31,68,69) |
| miR-17-5p | AIB1, E2F1, p21, BIM | Breast cancer, CLLa | (123–126) |
| miR-29 | MCL-1, TCL-1, DNMT3s | Lung and breast cancers, CLLa, AMLa | (124,127–129) |
| miR-124a | CDK6 | ALLa, medulloblastoma | (130,131) |
| miR-127 | Bcl-6 | Breast cancer, lymphoma | (123) |
| miR-143 | Ras, ERK5 | Gastric and prostate cancers | (132–134) |
| miR-145 | Mucin1, ERG | Breast and gastric cancers | (133,135–138) |
| miR-181 | TCL-1, E2F5, eIF5A | Colorectal cancer | (129) |
| Oncogenic activity | |||
| miR-21 | PTEN, TPM1, Pdcd4, maspin | Colon, breast, pancreatic, lung, prostate, liver, and gastric cancers | (37–48) |
| miR-155 | AT1R, TP53INP1 | Lung and breast cancers, CLLa, AMLa | (37,55–59) |
| miR-17-92 | Tsp1, CTGF, E2F1, AIB1, TGFBR2 | Lung, breast, colon, gastric, pancreatic cancers, lymphomas | (49–54) |
| miR-106a | RB-1 | Colon and gastric cancers | (139,140) |
| miR-373 | LATS2 | Testicular tumor, Gastric cancer | (141–143) |
| miR-197 | ACVR1, TSPAN3, FUS1 | Lung cancer | (144) |
| miR-221 | KIT, p27(Kip1), p57, PTEN | Breast and liver cancers, CLL | (43) |
| miR-222 | KIT, p27(Kip1), p57, PTEN | Breast and liver cancers, CLL | (57) |
| miR-372 | LATS2 | Testicular tumor | (143) |
a
CLL chronic lymphoblastic leukemia; AML acute myeloid leukemia; ALL acute lymphoblastic leukemia.