. Author manuscript; available in PMC: 2010 Nov 6.

Published in final edited form as: Pharm Res. 2010 Mar 20;27(6):1027–1041. doi: 10.1007/s11095-010-0105-y

Table 2.

List of miRNAs Altered by Natural Agents

Natural agents	Up-regulated miRNA	Down-regulated miRNA	References
Curcumin	miR-22, miR-34a, miR-24, miR-181a, miR-21, miR-181b, miR-27a	miR-199a, miR-510, miR-196a, miR-7, miR-15b, miR-195, miR-374, miR-98	(11)
I3C, DIM	miR-200b, miR-200c, let-7b, let-7c, let-7d, let-7e, miR-663, miR-638, miR-122, miR-149	miR-21, mir-31, miR-130a, miR-146b, miR-377, miR-20b, miR-654, miR-34c	(8)
Isoflavone	miR-200b, miR-200c, let-7b, let-7c, let-7d, let-7e, miR-663, miR-146a, miR-374b	miR-34c, miR-376a, miR-196a, miR-320, miR-654, miR-34c, miR-196	(7,8)
EGCG	let-7, miR-16, miR-18b, miR-20a, miR-25, miR-92, miR-93, miR-221, miR-320	miR-10a, miR-18a, miR-19a, miR-26b, miR-29b, miR-34b, miR-98, miR-129, miR-181d	(117)
Resveratrol		miR-146a	(10)
Alcohol, Vit E, folate and retinoids	miR-10a, miR-10b, miR-9, miR-145, miR-30a-3p, miR-152, miR-122a, miR-125b	miR-200a, miR-496, miR-296, miR-30e-5p, miR-362, miR-339, miR-29c, miR-154, miR-10a	(120–122)