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Simulated extreme hypothyroidism postthyroidectomy with 0.2% remaining TH secretion using the original model (top) (14), and SCR (middle) and DCR (bottom) models extended to the extreme-hypothyroid range. Original model shows exaggerated circadian rhythms, whereas circadian variation in the new models is restricted to at most ∼10 mU/L (SCR model) and further diminished with the DCR model.
