Table 2.
Raw (nonnormalized) FDG uptake in the 18-month-old 3xTG and wildtype mice, mean ± standard deviation.
| Wildtype | 3xTG * | |
|---|---|---|
| Whole brain average | 914 ± 131 | 669 ± 81 |
| Optic tract | 370 ± 111 | 256 ± 65 |
| Cingulate gyrus, retrosplenial | 1058 ± 152 | 755 ± 74 |
| Cingulate gyrus, posterior 2 | 1047± 114 | 786 ± 94 |
| Cingulate gyrus, posterior | 1054 ± 125 | 809 ± 95 |
| Cingulate gyrus, middle | 1064 ± 145 | 805 ± 101 |
| Cingulate gyrus, anterior | 929 ± 145 | 687 ± 80 |
| Posterior parietal cortex | 1003 ± 132 | 740 ± 106 |
| Lateral entorhinal cortex | 726 ± 128 | 518 ± 57 |
| 1° somatosensory cortex | 926 ± 141 | 671 ± 84 |
| 1° somatosensory, barrel fields | 1015 ± 121 | 771 ± 90 |
| 2° somatosensory cortex | 927 ± 128 | 704 ± 84 |
| 1° auditory cortex | 885 ± 118 | 625 ± 82 |
| 1° visual cortex, monocular | 1045 ± 145 | 781 ± 97 |
| Piriform cortex | 766 ± 126 | 535 ± 78 |
| CA1 | 759 ± 144 | 532 ± 76 |
| CA3 | 772 ± 143 | 519 ± 70 |
| Dentate gyrus | 807 ± 138 | 547 ± 79 |
| Subiculum | 906 ± 142 | 650 ± 83 |
| Medial mammillary nucleus | 1127 ± 97 | 911 ± 96 |
| Substantia nigra | 727 ± 132 | 490 ± 73 |
| Basolateral amygdala | 785 ± 137 | 542 ± 82 |
| Anteroventral thalamus | 1163 ± 148 | 900 ± 114 |
| Reticular thalamus | 1070 ± 163 | 813 ± 94 |
| Reuniens nucleus | 818 ± 159 | 624 ± 120 |
| Ventromedial thalamus | 1100 ± 137 | 869 ± 105 |
| Ventrolateral thalamus | 1080 ± 137 | 840 ± 107 |
| Mediodorsal thalamus | 1076 ± 140 | 814 ± 100 |
| Laterodorsal thalamus | 1144 ± 130 | 913 ± 100 |
| Lateral posterior thalamus | 1098 ± 152 | 837 ± 109 |
| Lateral habenula | 863 ± 151 | 632 ± 120 |
| Parafascicular thalamus | 1013 ± 139 | 740 ± 90 |
| Ventroposterolateral thalamus | 1023 ± 152 | 747 ± 108 |
| Ventroposteromedial thalamus | 1064 ± 155 | 775 ± 110 |
| Posterior thalamus | 1083 ± 139 | 802 ± 117 |
| Rostral caudoputamen | 920 ± 142 | 727 ± 78 |
| Caudal caudoputamen | 744 ± 143 | 430 ± 61 |
| Lateral globus pallidus | 747 ± 138 | 484 ± 75 |
| Subthalamus | 898 ± 116 | 722 ± 98 |
| Nucleus accumbens | 727 ± 133 | 531 ± 77 |
| Nuc. of vertical diagonal band | 834 ± 140 | 638 ± 84 |
| Medial septal nucleus | 872 ± 140 | 657 ± 82 |
| Lateral septal nucleus | 817 ± 154 | 582 ± 83 |
| Nucleus basalis | 746 ± 139 | 497 ± 71 |
| Anterior hypothalamus | 662 ± 136 | 452 ± 86 |
| Lateral hypothalamus | 763 ± 140 | 543 ± 75 |
| Dorsolateral geniculate | 1029 ± 128 | 784 ± 109 |
| Medial geniculate | 961 ± 171 | 691 ± 87 |
| Superior colliculus | 999 ± 158 | 719 ± 96 |
| Pontine nuclei | 800 ± 149 | 561 ± 85 |
| Inferior colliculus, central | 887 ± 150 | 683 ± 99 |
| Periaqueductal gray | 634 ± 138 | 408 ± 74 |
| Vestibular nuclei | 1059 ± 140 | 841 ± 98 |
| Reticular nucleus, giganto | 1070 ± 163 | 813 ± 94 |
| Cerebellar lobules 1-5 | 985 ± 142 | 650 ± 73 |
| Simple lobule | 734 ± 139 | 504 ± 71 |
| Crus 1 lobule | 728 ± 130 | 511 ± 69 |
*
3xTG mice demonstrated significantly lower FDG uptake than same-age wildtype in every region measured (2-tailed t-test, p<0.01, uncorrected for multiple comparisons).