Table 1.
Genes Expressed in Developing Orofacial Tissue Encoding Members of the TGFß Superfamily and their Associated Signaling Proteins.
| 1Gene | Affymetrix Probe ID# | Gen Bank Accession Number |
|---|---|---|
| Transcription factor 1 | 100082_at | M57966 |
| Jun oncogene | 100130_at | X12761 |
| T-complex protein 10c | 100359_at | M22602 |
| IQ motif containing GTPase activating protein 1 | 100561_at | AW209098 |
| Calpain, small subunit 1 | 100610_at | AF058298 |
| Luteinizing hormone/choriogonadotropin receptor | 100705_at | M81310 |
| Formyl peptide receptor, related sequence 2 (lipoxin A4 receptor-like protein) | 101800_at | AF071180 |
| Follicle stimulating hormone receptor | 101810_at | AF095642 |
| Mitogen activated protein kinase 3 | 101834_at | Z14249 |
| Transforming growth factor, beta 1 | 101918_at | AJ009862 |
| TGFß1-induced anti-apoptotic factor 1 | 102080_at | AF104984 |
| TGFß1-induced anti-apoptotic factor 2 (co-activator of nuclear receptors) | 102613_at | AF075717 |
| Tumor necrosis factor alpha | 102629_at | D84196 |
| Transforming growth factor, beta receptor III / betaglycan | 102637_at | AF039601 |
| Transforming growth factor, beta 3 | 102751_at | M32745 |
| E2F transcription factor 1 | 102963_at | L21973 |
| MAD homolog 1 (Drosophila) | 102983_at | U58992 |
| MAD homolog 1 (Drosophila) | 102984_g_at | U58992 |
| Latent transforming growth factor beta binding protein 1 | 103209_at | AF022889 |
| Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 104097_at | AF002823 |
| IQ motif containing GTPase activating protein 1 | 104300_at | AI117936 |
| src homology 2 domain-containing transforming protein C1 | 104350_at | AI050321 |
| MAD homolog 2 (Drosophila) | 104536_at | U60530 |
| Eukaryotic translation initiation factor 5 | 160265_at | AW123979 |
| Thrombospondin 1 (activator of TGFß) | 160469_at | M62470 |
| Harvey rat sarcoma virus oncogene 1 | 160536_at | Z50013 |
| Low density lipoprotein receptor | 160832_at | Z19521 |
| Mitogen activated protein kinase kinase kinase 7 | 160854_at | D76446 |
| Transforming growth factor, beta induced | 161157_r_at | AV231282 |
| Calpain 10 | 161307_f_at | AV350809 |
| Tryptophanyl-tRNA synthetase | 161337_f_at | AV121930 |
| Transforming growth factor, beta 3 | 161382_at | AV246832 |
| E2F transcription factor 1 | 161427_f_at | AV301683 |
| Prostaglandin F receptor | 161713_f_at | AV248803 |
| Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 162264_s_at | AV359014 |
| Retinoid X receptor gamma | 92237_at | X66225 |
| Latent transforming growth factor beta binding protein 2 | 92335_at | AF004874 |
| Transforming growth factor alpha | 92369_at | M92420 |
| Transforming growth factor, beta receptor I/ALK-5 | 92427_at | D25540 |
| Origin recognition complex, subunit 1-like (S.cereviaiae) | 92458_at | AJ00313 |
| Frequently rearranged in advanced T-cell lymphomas | 92695_at | U58974 |
| Transforming growth factor, beta induced | 92877_at | L19932 |
| Cyclin A1 | 92911_at | X84311 |
| Connective tissue growth factor | 93294_at | M70642 |
| Transforming growth factor, beta 2 | 93300_at | X57413 |
| Chemokine (C-C motif) receptor 2 | 93397_at | U56819 |
| MAD homolog 3 (Drosophila) | 93613_at | AB008192 |
| TGFß-induced factor 2 (TALE family homeobox) | 93621_at | AA914350 |
| src homology 2 domain-containing transforming protein C1 | 93713_at | U15784 |
| Transforming growth factor beta 1 induced transcript 4 | 93728_at | X62940 |
| IQ motif containing GTPase activating protein 1 | 93850_at | AI642553 |
| Glial cell line derived neurotrophic factor family receptor alpha 1 | 93872_at | AF014117 |
| Serine (or cysteine) proteinase inhibitor, clade E, member 1/ PAI-1 (SERPIN-1) | 94147_at | M33960 |
| TGFßRII | 94702_at | D32072 |
| WNT1 inducible signaling pathway protein 2 / connective tissue growth factor related protein WISP-2 | 94704_at | AF100778 |
| Cell division cycle 20 homolog (S. cerevisiae) | 96319_at | AW061324 |
| Oxoglutarate dehydrogenase (lipoamide) | 96879_at | AI852338 |
| RIKEN cDNA 5730427N09 gene | 97229_at | AW061042 |
| Calpain 10 | 97331_at | AW049679 |
| Latent transforming growth factor beta binding protein 4 | 97347_at | AA838868 |
| Eukaryotic translation elongation factor 2 | 97559_at | M76131 |
| Prostaglandin F receptor | 97769_at | D17433 |
| Forkhead box H1 | 97789_at | AF069303 |
| Transforming growth factor beta 1 induced transcript 1 | 98019_at | L22482 |
| Nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 | 98427_s_at | M57999 |
| Tryptophanyl-tRNA synthetase | 98606_s_at | X69656 |
| Glycerol phosphate dehydrogenase 2, mitochondrial | 98984_f_at | D50430 |
| Fumarate hydratase 1 | 99148_at | AI852862 |
| Interferon gamma | 99334_at | K00083 |
| Guanine nucleotide binding protein (G protein), gamma 12 | 99477_at | AI842738 |
| TGFß inducible early growth response 1 (Kruppel-like factor 10) | 99602_at | AF064088 |
| TGFß inducible early growth response 1 (Kruppel-like factor 10) | 99603_g_at | AF064088 |
| Prostaglandin F2 receptor negative regulator | 99894_at | AF006201 |
| MAD homolog 5 (Drosophila) | 102865_at | U58993 |
| MAD homolog 1 (Drosophila) | 102983_at | U58992 |
| MAD homolog 1 (Drosophila) | 102984_g_at | U58992 |
| MAD homolog 6 (Drosophila) | 104220_at | AF010133 |
| Smad nuclear interacting protein 1 | 104349_at | AA870301 |
| MAD homolog 2 (Drosophila) | 104536_at | U60530 |
| MAD homolog 4 (Drosophila) | 160440_at | U79748 |
| MAD homolog 7 (Drosophila) | 92216_at | AF015260 |
| Spectrin beta 2 | 93571_at | M74773 |
| MAD homolog 3 (Drosophila) | 93613_at | AB008192 |
| Zinc finger, FYVE domain containing 16 | 96491_at | AI035632 |
| Decorin (TGFb inhibitor) | 93534_at | X53929 |
| Biglycan (inhibitor) | 96049_at | X53928 |
| alpha 2-Macroglobulin (Clearance factor) | 104486_at | AI850558 |
| Endoglin (signal modulator of TGFßs, Activins, BMPs etc.) | 100134_at | X77952 |
| Nodal | 99801_at | X70514 |
| Nodal Modulator 1 (Nomo 1) | 104140_s_at | AI846989 |
| SARA (Smad anchor for receptor activation) | 96491_at | AI035632 |
| Apolipoprotein J / Clusterin (role in TGFß signaling &/or processing) | 95286_at | D14077 |
| Furin (Proprotein convertase subtilisin/kexin type 3) (TGFß precursor cleavage and activation) | 100515_at | X54056 |
| Dachshund-1 | 94179_at | AJ005669 |
| SKIP | 104158_at | AW046671 |
| SnoN | 94752_s_at | U10531 |
| Lefty-1 (Leftb) | 102345_at | D83921 |
| Fkbpl; FK506 binding protein-like | 102206_at | AF030001 |
| Notch-1 | 97497_at | Z11886 |
| Notch-2 | 104188_at | AI853703 |
| Notch-3 | 92956_at | X74760 |
| Notch-4 | 92652_at | AF030001 |
| Evi-1 | 100754_at | X54989 |
| Evi-1 | 99391_at | M21829 |
| Jagged2 | 92510_at | Y14331 |
| Sin3A | 103011_at | L36831 |
| Sin3B | 93790_at | L38622 |
| Cited-2 | 101973_at | Y15163 |
| Cited-1 | 160705_at | U65091 |
| CREM (cAMP responsive element modulator) | 100533_s_at | M60285 |
| CREM (cAMP responsive element modulator) | 160526_s_at | M60285 |
| CREBBP/EP300 inhibitory protein 1 or Cri1 | 99191_at | AI844939 |
| CD79A antigen (immunoglobulin-associated alpha; TGFß family receptor) | 102778_at | X13450 |
| Integrin beta-5 | 100601_at | AF022110 |
| Integrin beta 7 | 100906_at | M68903 |
| Nuclear receptor subfamily 0, group B, member 1 (NrOb1) | 93141_at | U41568 |
| Cyclin-dependent kinase inhibitor 1A (P21 or Cdkn1a) | 94881_at | AW048937 |
| Cyclin-dependent kinase inhibitor 1A (P21 or Cdkn1a) | 98067_at | U09507 |
| Cyclin dependent kinase inhibitor 2B (P15 or Cdkn2b) | 101900_at | AF059567 |
| Cyclin dependent kinase inhibitor p16INK4a (P16 or Cdkn2a) | 98789_at | AF044336 |
| Procollagen type I, alpha 1 | 94305_at | U03419 |
| Procollagen, type I, alpha 2 | 101130_at | X58251 |
| Procollagen, type III, alpha 1 | 102990_at | AA655199 |
| Procollagen, type III, alpha 1 | 98331_at | X52046 |
| Fos (FBJ osteosarcoma oncogene) | 160901_at | V00727 |
| Fos (FBJ osteosarcoma oncogene) | 161716_at | AV252296 |
| FosB (FBJ osteosarcoma oncogene B) | 103990_at | X14897 |
| Goosecoid | 94187_at | M85271 |
| Involucrin (keratinocyte differentiation) | 92739_at | L28819 |
| Jun oncogene | 100130_at | X12761 |
| Plasminogen activator, tissue | 93981_at | J03520 |
| Urokinase-type plasminogen activator protein gene | 97772_at | M17922 |
| TGIF (TG interacting factor) | 101502_at | X89749 |
| Tissue inhibitor of metalloproteinase 1 (Timp1) | 101464_at | V00755 |
| c-myc | 104712_at | L00039 |
| FK506-binding protein 1b (protein folding) | 103248_at | AF060872 |
| Leucine aminopeptidase 3; Lap3; (proteolysis and peptidolysis) | 98112_r_at | AI839225 |
| HDAC-1 | 97706_at | AA474655 |
| HDAC-1 | 96046_at | X98207 |
| HDAC-2 | 160643_at | U31758 |
| HDAC-3 | 103655_at | AF074882 |
| HDAC-5 | 104376_at | AF006602 |
| HDAC-6 | 104471_at | AF006603 |
| HDAC-7A | 97550_at | AW047228 |
| CBP | 95886_g_at | AA177826 |
| p300/CBP-associated factor (Pcaf) | 104070_at | AW047728 |
| NCoR-1 | 101536_at | U35312 |
| NCoR-2 | 95129_at | AW121057 |
| MMP2 (gelatinase A) | 161509_at | AV145762 |
| MMP9 (gelatinase B) | 99957_at | X72795 |
| Bone morphogenetic protein 8b | 101657_at | U39545 |
| Gremlin 1 | 101758_at | AF045801 |
| Bone morphogenetic protein 10 | 101815_at | AF101440 |
| Twisted gastrulation homolog 1 (Drosophila) | 102032_at | AW060819 |
| Bone morphogenetic protein 2 | 102559_at | L25602 |
| Bone morphogenetic protein 6 | 161028_at | AI850533 |
| Solute carrier family 29 (nucleoside transporters), member 1 | 161687_r_at | AV217246 |
| Bone morphogenetic protein 6 | 92372_at | X80992 |
| Bone morphogenetic protein 15 or GDF-9B | 92485_at | AJ010259 |
| Bone morphogenetic protein 1 | 92701_at | AA518586 |
| Bone morphogenetic protein receptor, type 1A or ALK-3 | 92767_at | D16250 |
| Solute carrier family 29 (nucleoside transporters), member 2 | 92950_at | X86682 |
| Bone morphogenetic protein 8a | 92982_at | M97017 |
| Bone morphogenetic protein 7 | 93243_at | X56906 |
| BMP2 inducible kinase | 93376_at | AA673486 |
| Bone morphogenetic protein 4 | 93455_s_at | X56848 |
| Bone morphogenetic protein 4 | 93456_r_at | L47480 |
| Bone morphogenetic protein 1 | 95557_at | L24755 |
| Solute carrier family 29 (nucleoside transporters), member 1 | 95733_at | AI838274 |
| Protease, serine, 11 (Igf binding) | 96920_at | AW125478 |
| Bone morphogenetic protein receptor, type 1B or ALK-6 | 97725_at | Z23143 |
| Noggin | 97727_at | U79163 |
| Bone morphogenetic protein 5 | 99393_at | L41145 |
| Transducer of ErbB-2.1 | 99532_at | D78382 |
| Bone morphogenetic protein receptor, type II (serine/threonine kinase) | 99865_at | AF003942 |
| Runx1 (Core binding factor alpha 2) | 92399_at | D26532 |
| Runx2 (Core binding factor alpha 1) | 92676_at | D14636 |
| Runx2 | 92677_s_at | AF010284 |
| Runx2 | 161378_r_at | AV245229 |
| Chordin (inhibitor of BMP signaling/ ligand-receptor interaction) | 103249_at | AF069501 |
| Cerberus 1(inhibitor of BMP & activin signaling/ ligand-receptor interaction) | 93452_at | AF031896 |
| DAN or NBL1 (inhibitor of BMP signaling; like Gremlin); | 101969_at | D50263 |
| Gremlin 2 or PRDC | 103975_at | AB011030 |
| Bone gamma-carboxyglutamate protein 2 | 102801_at | L24430 |
| Idb-1 | 100050_at | M31885 |
| Idb-2 | 93013_at | AF077861 |
| Idb-3 | 92614_at | M60523 |
| Idb-4 | 96144_at | AJ001972 |
| Sox-4 | 160109_at | X70298 |
| Signal transducer and activator of transcription 1 (Stat1) | 101465_at | U06924 |
| Signal transducer and activator of transcription 4 (Stat4) | 102994_at | U06923 |
| Signal transducer and activator of transcription 3 (Stat3) | 99099_at | U08378 |
| PIAS1 (protein inhibitor of activated STAT protein 1) | 99029_at | AF077950 |
| PIAS3 (protein inhibitor of activated STAT protein 3) | 93708_at | AF034080 |
| Signal transducer and activator of transcription 5B (Stat 5b) | 92199_at | U21110 |
| Signal transducer and activator of transcription 5A (Stat 5a) | 100422_i_at | AJ237939 |
| Signal transducer and activator of transcription 5A (Stat 5a) | 100423_f_at | AJ237939 |
| Zinc finger homeobox 1a (Zfhx1a or Zfhep) or Transcription factor 8 | 99052_at | D76432 |
| Cyclin-dependent kinase inhibitor p27kip1 (Cdkn1b) | 100278_at | U09968 |
| Msx1 | 101526_at | X14759 |
| Msx2 | 102956_at | X59252 |
| Msx3 | 92912_at | X96518 |
| Msx-interacting-zinc finger protein 1 (Miz1) (Transcription Factor) | 100941_at | AF039567 |
| Dlx2 | 92332_at | M80540 |
| Dlx3 | 99328_at | U79738 |
| Dlx5 | 92930_at | U67840 |
| Dlx6 | 98866_at | U67841 |
| Homeodomain-interacting protein kinase 2 (HIPK-2) [BMP Co-repressor] | 103833_at | AF077659 |
| Homeodomain-interacting protein kinase 3 (HIPK-3) | 103233_at | AF077660 |
| Inhibin beta-A | 100277_at | X69619 |
| Activin A receptor, type II-like 1 (ALK-1) | 100448_at | Z31664 |
| Activin A receptor, type II-like 1 | 100449_g_at | Z31664 |
| Activin A receptor, type II-like 1 | 100450_r_at | L48015 |
| Activin A receptor, type 1B or ALK-4 (binds Activins & Nodal) | 101177_at | Z31663 |
| Synaptojanin 2 binding protein | 101548_at | AI846345 |
| Inhibin beta-C | 103986_at | X90819 |
| RIKEN cDNA 1810020G14 gene | 160556_at | AW048976 |
| Inhibin beta-B | 160828_at | X69620 |
| Activin A receptor, type 1 / TGFb type I receptor (ALK-2, ALK-8) | 93460_at | L15436 |
| Activin receptor IIB | 93903_at | M84120 |
| Synaptojanin 2 binding protein | 96734_at | AA674143 |
| Inhibin beta E | 97153_at | U96386 |
| Forkhead box H1 (Fast2; forkhead-activin signal transducer 2) | 97789_at | AF069303 |
| Activin receptor IIA | 98841_at | M65287 |
| Beta-microseminoprotein (beta-inhibin; prostatic inhibin protein) | 100715_at | U89840 |
| Inhibin alpha | 102266_at | X55957 |
| Transmembrane protein with EGF-like and two follistatin-like domains 2 | 103536_at | AB017270 |
| Follistatin-like 3 | 104452_at | AI845896 |
| Transmembrane protein with EGF-like and two follistatin-like domains 1 | 160472_r_at | AI837838 |
| Follistatin-like 1 | 94833_at | M91380 |
| Follistatin | 98817_at | Z29532 |
| Growth differentiation factor 11 | 101814_at | AF100906 |
| Growth differentiation factor 15 | 104646_at | AJ011967 |
| Growth differentiation factor 9 | 160567_at | L06444 |
| Growth differentiation factor 10 | 160860_at | AI853332 |
| Growth differentiation factor 3 | 161144_r_at | AV217223 |
| Growth differentiation factor 3 | 92476_at | L06443 |
| Growth differentiation factor 1 /// longevity assurance homolog 1 (S. cerevisiae) | 93642_at | M62301 |
| Growth differentiation factor 8 / Myostatin | 97155_at | U84005 |
| Thrombopoietin | 97734_at | L34169 |
| Hepatoma-derived growth factor, related protein 2 | 98599_at | D63850 |
| Growth differentiation factor 5 | 98793_at | U08337 |
| Anti-Mullerian hormone | 101765_at | X63240 |
| IGF-1 | 95545_at | X04480 |
| IGFBP-3 | 95083_at | X81581 |
| Interleukin 6 | 102218_at | X54542 |
| PDGFs | 99890_at | M64849 |
1
All constitutively- and differentially-expressed genes encoding members of the TGFß superfamily and their functionally associated signaling proteins from GD-12, GD-13 and GD-14 developing orofacial tissue (n=3 for each gestational day). Only those genes which demonstrated statistically significant expression in the tissue on at least one of the three days of gestation in all three biological replicates (n=3) are included in this table.