Table 2.
Univariate and multivariate analyses for factors associated with time to CD4 recovery to ≥25%
| Univariate | Multivariate | |||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| ≥156 months of age | 1 | … | 1 | … |
| 60–155 months of age | 1.6 (1.1 – 2.3) | 0.013 | 2.1 (1.4 – 3.2) | 0.001 |
| 18–59 months of age | 1.8 (1.2 – 2.6) | 0.003 | 2.1 (1.3 – 3.3) | 0.001 |
| <18 months of age | 4.4 (2.9 – 6.6) | <0.001 | 3.8 (2.4 – 6.2) | <0.001 |
| Female | 1.3 (1.1 – 1.5) | <0.001 | 1.4 (1.2 – 1.7) | <0.001 |
| Infant ARV for PMTCT | 2.0 (1.6 – 2.6) | <0.001 | ||
| Maternal ARV for PMTCT | 1.7 (1.3 – 2.2) | <0.001 | ||
| No history of mono/dual | ||||
| ART | 1.3 (1.1 – 1.6) | 0.015 | 1.8 (1.4 – 2.3) | <0.001 |
| Single orphan | 0.8 (0.7 – 0.9) | 0.003 | ||
| Double orphan | 0.8 (0.7 – 1.0) | 0.029 | ||
| Weight for age z score1, per 5 unit change |
1.3 (0.9 – 1.7) | 0.157 | ||
| Height for age z score, per 5 | ||||
| unit change | 1.1 (0.9 – 1.2) | 0.509 | ||
| Baseline BMI, per 5 unit change |
1.0 (0.9 – 1.1) | 0.431 | ||
| WHO Stage | 0.021 | |||
| Stage I | 1 | |||
| Stage II | 0.9 (0.7 – 1.3) | 0.667 | ||
| Stage III | 0.8 (0.6 – 1.0) | 0.049 | ||
| Stage IV | 0.7 (0.5 – 1.0) | 0.029 | ||
| CD4% at baseline per 10% change |
2.0 (1.9 – 2.2) | <0.001 | 2.0 (1.9 – 2.2) | <0.001 |
1
using WHO 1977 growth standards
Abbreviations: HR-hazard ratio; CI-confidence interval; ARV-antiretroviral; ART-antiretroviral therapy; PMTCT-prevention of mother-to-child transmission; BMI-body mass index.