Table 4.

Randomized clinical trials in patients with chronic myocardial ischemia.

Trial	N	Cell type	Delivery	Timing	Primary endpoint	Comments
Losordo [24]	24	CD34+	transendo	chronic	Improved angina parameters	No clear perfusion benefit
PROTECT-CAD [25]	28	BMMC	transendo	chronic	Improved angina parameters	Improved LVEF and perfusion
Van Ramshorst [26]	50	BMMC	transendo	chronic	Improved angina parameters	Improved LVEF and perfusion

BMMC: bone marrow mononuclear cells; LVEF: left ventricular ejection fraction.