Table III.

Selection Pressure (dN/dS Ratios) of Significant C-Lobe Structural Elements within the TF Family

C-lobe	Fe-binding				Anion		Triad			Hinge
Residue	Asp	Tyr	Tyr	His	Thr	Arg	Lys	Arg	Asp	Ala	Gly	Arg	Ala	Pro
Human TF	392	426	517	585	452	456	534	632	634	424	425	581	582	583
Mouse ICA	386	427	Ser 520	Arg 588	453	Thr 457	537	Ser 653	636	Glu 425	426	584	Val 585	586
TF (n = 18)	0.05	0.08	0.07	0.05	0.04	0.05	0.06	0.16	0.19	1.10	0.31	1.50	0.47	0.09
LTF (n = 14)	0.09	0.13	0.11	0.08	0.06	0.06	0.11	0.07 (N)	0.05 (N)	0.82 (E)	0.12	0.89 (M)	0.2	0.13
MTF (n = 11)	0.68 (S)	0.03	0.41	0.19	0.44 (A)	0.02 (S)	0.14 (R)	0.03 (K)	0.02 (A)	0.21 (N)	0.02 (S)	0.02 (Q)	0.31 (I)	0.06
ICA (n = 7)	0.06	1.20	1.50 (S)	1.1 (R)	1.50	0.11 (T)	0.05	0.08 (S)	0.68	1.40 (E)	0.11	1.50	0.07 (V)	0.26