Table III.
Structure (Ligand) |
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Closed conformers |
Open/partially open conformers |
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Hot spot | 1P5Da (G1P) | 1P5Ga (G6P) | 1PCJa (M1P) | 1PCMa (M6P) | 2H4La (R1P) | 2H5Aa (X1P) | 2FKM (G16P) | 2FKFa (G16P) | 1K35a | 1K2Y |
AS | 2 (32) | 1 (30) | 1 (35) | 2 (26) | 2 (27) | 2 (30) | 3 (25) | 1 (36) | 3 (22) | 5 (12) |
H1 | 5 (7) | 3 (26) | 6 (10) | 4 (20) | 7 (7) | 2 (27) | 4 (19) | 3 (22) | 4 (14) | |
H2 | 6 (13) | 4 (19) | 2 (17) | |||||||
D123 | 1 (42) | 2 (27) | 1 (35) | 1 (39) | 1 (42) | 1 (35) | 1 (38) | 2 (30) | 1 (27) | 5 (12) |
D13 | 5 (17) | 5 (14) | 3 (16) | |||||||
D14 | 5 (7) | 7 (5) | 7 (8) | 5 (8) | 5 (9) | |||||
D23 | 3(20) | 2 (24) | 1 (29) | |||||||
D34 | 3 (24) | 1 (30) | 3 (18) | 5 (19) | 3 (20) | 3 (27) | 4 (16) | |||
D4 | 4 (18) | 4 (18) | 2 (20) | 3 (21) | 4 (16) | 4 (14) | 5 (10) |
Denotes phosphorylated form of enzyme. Rank of each hot spot is indicated in column below each structure, with the number of probes in the hot spot shown in parentheses. The top three hot spots for each structure are shown in red, orange, and green font, respectively. Hot spots with fewer than five probe clusters are not included. For hot spot definitions, see Table II. For the closed conformers, hot spots found in only one or two structures are omitted for clarity.