Table III.
Minimal Inhibitory Concentrations of Carbapenems (mg/L) for Variants Expressed from pBR322-catI-blaKPC-2 in E. coli DH10B
| Strain | IMPa | MEMa | ERTa | DORa |
|---|---|---|---|---|
| E. coli DH10B pBR322-catI-blaKPC-2a | 4 | 2 | 2 | 4 |
| Trp105Ala | 2 | 0.25 | 0.5 | 0.5 |
| Trp105Ile | 2 | 0.25 | 0.5 | 0.5 |
| Trp105Leu | 2 | 0.25 | 0.25 | 0.5 |
| Trp105Met | 2 | 0.5 | 0.5 | 1 |
| Trp105Val | 2 | 0.25 | 0.5 | 0.5 |
| Trp105Cys | 2 | 0.125 | 0.5 | 0.5 |
| Trp105Asn | 2 | 0.5 | 0.5 | 1 |
| Trp105Pro | 2 | 0.25 | 0.5 | 0.5 |
| Trp105Gln | 2 | 0.25 | 0.25 | 0.5 |
| Trp105Ser | 2 | 0.25 | 0.25 | 0.5 |
| Trp105Thr | 2 | 0.25 | 0.5 | 0.5 |
| Trp105Phe | 4 | 1 | 1 | 1 |
| Trp105Glu | 2 | 0.5 | 0.25 | 1 |
| Trp105His | 4 | 0.5 | 0.5 | 0.5 |
| Trp105Lys | 1 | 0.125 | 0.125 | 0.25 |
| Trp105Arg | 1 | 0.125 | 0.25 | 0.25 |
| E. coli DH10B | 0.25 | 0.06 | 0.06 | 0.06 |
a
β-lactam abbreviations: IMP, imipenem; MEM, meropenem; ERT, ertapenem; and DOR, doripenem.